220173-84-2 Usage
General Description
1-Difluoromethyl-2-phenyl-imidazole is a chemical compound with the molecular formula C9H6F2N2. It is an imidazole derivative with a difluoromethyl substituent at the 1-position and a phenyl group at the 2-position. 1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE has potential applications in pharmaceuticals, as imidazole derivatives are known to exhibit various biological activities, such as antimicrobial, antifungal, and anticancer properties. Additionally, the difluoromethyl group can enhance the stability and lipophilicity of the compound, making it a potential candidate for drug development. However, further studies are needed to fully understand the pharmacological and toxicological properties of 1-difluoromethyl-2-phenyl-imidazole.
Check Digit Verification of cas no
The CAS Registry Mumber 220173-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,1,7 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 220173-84:
(8*2)+(7*2)+(6*0)+(5*1)+(4*7)+(3*3)+(2*8)+(1*4)=92
92 % 10 = 2
So 220173-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8F2N2/c11-10(12)14-7-6-13-9(14)8-4-2-1-3-5-8/h1-7,10H
220173-84-2Relevant articles and documents
N-difluoromethylation of phenylazoles
Lyga, John W.,Patera, Russell M.
, p. 141 - 145 (1998)
In the presence of one equivalent of NaH, 2- and 4-phenylimidazole and 3-phenyl-1,2,4-triazole can be N-difluoromethylated with ClCF2H. The difluoromethylation of 5-phenyltetrazole requires two equivalents of NaH. A mechanism is proposed to acc
Method for synthesizing N-difluoromethyl-containing compound
-
Paragraph 0046-0049, (2019/12/02)
The invention discloses a method for synthesizing a N-difluoromethyl-containing compound. The method comprises reacting a nitrogen-containing nucleophilic reagent as shown in a formula I or III or V as a starting material for 6-24 hours in the presence of
Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation
Deng, Xiao-Yun,Lin, Jin-Hong,Zheng, Jian,Xiao, Ji-Chang
supporting information, p. 8805 - 8808 (2015/05/20)
Difluoromethylation of the activated X-H bond (X = N, O and S) and aliphatic thiols, and gem-difluorocyclopropenation of alkynes with difluorocarbene generated in situ from difluoromethylene phosphobetaine (Ph3P+CF2CO2-) by decarboxylation occurred smoothly without the presence of any base or other additives.
