220227-98-5

Basic information

• Product Name: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 4-Formyl-2-(trifluoromethyl)phenol, 5-Formyl-2-hydroxybenzotrifluoride;4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS NO: 220227-98-5
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.12
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);pharmacetical
• Mol File: 220227-98-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 159-163°C
• Boiling Point: 223.989 °C at 760 mmHg
• Flash Point: 89.266 °C
• Appearance: /
• Density: 1.429 g/cm³
• Vapor Pressure: 0.0626mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.79±0.43(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE(220227-98-5)
• EPA Substance Registry System: 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE(220227-98-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 220227-98-5(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-3-(trifluoromethyl)benzaldehyde is a chemical compound with the formula C8H5F3O2. It is a white to light yellow solid with a melting point of 89-91°C. It is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZALDEHYDE is also known for its use as a building block in the development of various heterocyclic compounds. It is important to handle this chemical with caution due to its potential hazards, and proper safety precautions should be followed when working with it.

InChI:InChI=1/C8H5F3O2/c9-8(10,11)6-3-5(4-12)1-2-7(6)13/h1-4,13H

Upstream product

• 1243458-14-1 C₈H₇F₃O 
• 444-30-4 2-(trifluoromethyl)phenol 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 50823-87-5 3-(trifluoromethyl)-4-methoxybenzaldehyde 
• 1283119-25-4 4-hydroxy-3-nitro-5-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

ARYLALKYL- AND CYCLOALKYLALKYL-PIPERAZINE DERIVATIVES AND METHODS OF THEIR USE

The present invention is directed to arylalkyl- and cycloalkylalkyl-piperazine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, int