220235-68-7Relevant articles and documents
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
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Page/Page column 129; 130, (2019/07/20)
The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.
Polyoxygenated Tertiary Alcohols: A Kiyooka Approach
Lücke, Daniel,Kalesse, Markus
supporting information, p. 10080 - 10083 (2019/07/18)
A Kiyooka aldol approach for the stereoselective synthesis of tertiary alcohols is presented. This approach allows for the incorporation of different substituents at all three remaining positions at the chiral center bearing the tertiary alcohol. To demon
Structure determination and total synthesis of (+)-16-hydroxy-16,22- dihydroapparicine
Hirose, Tomoyasu,Noguchi, Yoshihiko,Furuya, Yujiro,Ishiyama, Aki,Iwatsuki, Masato,Otoguro, Kazuhiko,Omura, Satoshi,Sunazuka, Toshiaki
supporting information, p. 10741 - 10750 (2013/08/23)
Herein, we describe the first asymmetric total synthesis and determination of the relative and absolute stereochemistry of naturally occurring 16-hydroxy-16,22-dihydroapparicine. The key steps include 1) a novel phosphinimine-mediated cascade reaction to