22034-63-5

Basic information

• Product Name: estradiol 3-propyl ether
• Synonyms: estradiol 3-propyl ether
• CAS NO: 22034-63-5
• Molecular Formula: C21H30 O2
• Molecular Weight: 0
• Mol File: 22034-63-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 453.5°Cat760mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.079g/cm³
• Vapor Pressure: 5.16E-09mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: estradiol 3-propyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: estradiol 3-propyl ether(22034-63-5)
• EPA Substance Registry System: estradiol 3-propyl ether(22034-63-5)

Safety Data

• Hazardous Substances Data: 22034-63-5(Hazardous Substances Data)

Usage

Description

Estradiol 3-propyl ether is a derivative of 17β-Estradiol (E888000), which is the primary estrogen hormone secreted by the premenopausal ovary. estradiol 3-propyl ether is known for its hormonal properties and potential applications in various fields due to its estrogenic activity.

Uses

Used in Pharmaceutical Industry:
Estradiol 3-propyl ether is used as a pharmaceutical compound for its estrogenic effects. It can be utilized in the development of medications targeting conditions related to hormonal imbalances or deficiencies, such as menopausal symptoms, osteoporosis, and certain reproductive disorders.
Used in Hormone Replacement Therapy:
In the healthcare industry, estradiol 3-propyl ether is used as a component in hormone replacement therapy (HRT) to alleviate symptoms associated with estrogen deficiency, such as hot flashes, night sweats, and vaginal dryness in postmenopausal women.
Used in Research and Development:
Estradiol 3-propyl ether is also used as a research tool in the field of endocrinology and reproductive biology. It can help scientists study the effects of estrogen on various physiological processes and develop a better understanding of its role in the body.
Used in Cosmetics Industry:
In the cosmetics industry, estradiol 3-propyl ether may be used as an ingredient in anti-aging products due to its potential estrogenic effects on the skin, which could help improve skin elasticity and reduce the appearance of wrinkles.
Please note that the use of estradiol 3-propyl ether in any application should be carefully considered and regulated, as with any hormone-related compound, due to potential side effects and health risks.

InChI:InChI=1/C21H30O2/c1-3-12-23-15-5-7-16-14(13-15)4-6-18-17(16)10-11-21(2)19(18)8-9-20(21)22/h5,7,13,17-20,22H,3-4,6,8-12H2,1-2H3/t17-,18-,19+,20+,21+/m1/s1

Upstream product

• 1034000-81-1 3-allyloxy-17β-hydroxy-1,3,5(10)-estratriene 
• 50-28-2 estradiol 
• 106-94-5 propyl bromide 
• 241147-96-6 2-(4-(tert-butyl)phenyl)benzo[d][1,3,2]dioxaborole 
• 598-05-0 di-1-propyl sulfate 

Relevant articles and documents

Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature

Textbook catalytic hydrogenations are typically presented as reactions done in organic solvents and oftentimes under varying pressures of hydrogen using specialized equipment. Catalysts new and old are all used under similar conditions that no longer reflect the times. By definition, such reactions are both environmentally irresponsible and dangerous, especially at industrial scales. We now report on a general method for chemoselective and safe hydrogenation of olefins in water using ppm loadings of palladium from commercially available, inexpensive, and recyclable Pd/C, together with hydrogen gas utilized at 1 atmosphere. A variety of alkenes is amenable to reduction, including terminal, highly substituted internal, and variously conjugated arrays. In most cases, only 500 ppm of heterogeneous Pd/C is sufficient, enabled by micellar catalysis used in recyclable water at room temperature. Comparison with several newly introduced catalysts featuring base metals illustrates the superiority of chemistry in water.

Enhanced Reactivity of Aerobic Diimide Olefin Hydrogenation with Arylboronic Compounds: An Efficient One-Pot Reduction/Oxidation Protocol

A catalyst-free and efficient method for simultaneous olefin hydrogenation and oxidation of arylboronate esters to phenols with hydrazine hydrate and molecular oxygen is presented. The process is based on the utilization of a readily available Lewis acidic arylboron compound, which evades common problems associated with the catalyst-free aerobic hydrogenation of olefins with diimide. Using an operationally simple procedure, the protocol smoothly delivers phenol derivatives and various alkanes in excellent yields with remarkable functional group compatibility. The method allows the reaction to be scaled up to 1 g of the starting materials.

Oestratriene diethers

3,17-Estratriene diethers, useful as anti-seborrheic and gynecological agents, is described.