22042-72-4

Basic information

• Product Name: 2-(2-HYDROXYETHOXY)BENZALDEHYDE
• Synonyms: 2-(2-HYDROXYETHOXY)BENZALDEHYDE;AKOS B030689;2-(2-hydroxyethoxy)benzaldehyde96+%
• CAS NO: 22042-72-4
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Mol File: 22042-72-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 45 °C
• Boiling Point: 134 °C / 1mmHg
• Flash Point: 134.1°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 8.69E-05mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Refrigerator
• PKA: 14.20±0.10(Predicted)
• CAS DataBase Reference: 2-(2-HYDROXYETHOXY)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-HYDROXYETHOXY)BENZALDEHYDE(22042-72-4)
• EPA Substance Registry System: 2-(2-HYDROXYETHOXY)BENZALDEHYDE(22042-72-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-52-43-36
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 22042-72-4(Hazardous Substances Data)

Usage

General Description

2-(2-HYDROXYETHOXY)BENZALDEHYDE, also known as 2-Hydroxyethoxybenzaldehyde, is a chemical compound with the molecular formula C9H10O3. It is a white to pale yellow solid with a floral, fruity odor. 2-(2-HYDROXYETHOXY)BENZALDEHYDE is commonly used in the fragrance and flavor industry as a fragrance ingredient, and it is also used in the production of personal care products, cosmetics, and various household items. Additionally, 2-(2-HYDROXYETHOXY)BENZALDEHYDE has potential applications in the pharmaceutical and agricultural sectors. However, it is important to handle this chemical with care, as it can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C9H10O3/c10-5-6-12-9-4-2-1-3-8(9)7-11/h1-4,7,10H,5-6H2

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 107-07-3 2-chloro-ethanol 
• 98954-44-0 2-[o-(hydroxymethyl)phenoxy]ethanol 
• 122-99-6 2-Phenoxyethanol 
• 68-12-2 N,N-dimethyl-formamide 
• 96-49-1 [1,3]-dioxolan-2-one 
• 90-02-8 salicylaldehyde 
• 3116-83-4 sodium salicylate 
• 540-51-2 2-bromoethanol 

Downstream Products

• 4591-16-6 diphenylfumaronitrile 
• 116748-60-8 4-Methyl-benzoic acid 2-(2-formyl-phenoxy)-ethyl ester 
• 102941-67-3 C₁₈H₁₆O₆ 
• 22891-52-7 2H-benzo[e][1,4]dioxepin-5(3H)-one 
• 98954-44-0 2-[o-(hydroxymethyl)phenoxy]ethanol 
• 116748-57-3 3-Nitro-benzenesulfonic acid 2-(2-formyl-phenoxy)-ethyl ester 
• 62222-09-7 bis-2-(2-formylphenoxy)ethyl terephthalate 
• 55022-79-2 1,2,4,5-tetrakis<2-(2-formylphenoxy)ethyl)>benzenetetracarboxylate 
• 94526-88-2 Benzene-1,2,4,5-tetracarboxylic acid bis-[2-(2-formyl-phenoxy)-ethyl] ester 
• 116748-56-2 4-Fluoro-benzenesulfonic acid 2-(2-formyl-phenoxy)-ethyl ester 
• 81677-66-9 meso-tetra (2-(2-propionoxyethoxy)phenyl)porphine 
• 160969-03-9 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene 
• 1095003-82-9 N-cyclopropyl-4-methyl-3-[2-oxo-3-{[(1R)-1-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propyl]amino}pyrazin-1(2H)-yl]benzamide 

Relevant articles and documents

Preparation method of silodosin intermediate

The invention discloses a preparation method of a silodosin intermediate and relates to the technical field of chemical synthesis of drugs. The preparation method comprises the following steps: subjecting salicyaldehyde and ethylene carbonate to transesterification to obtain 2-(2-hydroxyethoxy)benzaldehyde; then, carrying out a Dakin oxidation reaction to obtain sodium 2-(2-hydroxyethoxy) phenol;then, subjecting sodium 2-(2-hydroxyethoxy) phenol and trifluoroethanol to an etherification reaction to obtain 2-[2-(2,2,2-trifluoroethyoxy)phenoxy]ethyl alcohol; and finally, subjecting 2-[2-(2,2,2-trifluoroethyoxy)phenoxy]ethyl alcohol and methanesulfonyl chloride to an esterfication reaction to obtain the silodosin intermediate 2-[2-(2,2,2-trifluoroethyoxy)phenoxy]ethyl methanesulfonate. The preparation method is novel and short in synthesis route, and a target product can be prepared by only four-step reaction. Both raw materials and reagents used for preparation are cheap, available andenvironment-friendly, all the reaction conditions are mild and controllable, the preparation method is convenient and simple in operation, and the prepared silodosin intermediate is high in purity andyield, suitable for industrial production and wide in prospect and industrial application value.

N-heterocyclic carbene catalyzed nucleophilic substitution reaction for construction of benzopyrones and benzofuranones

N-Heterocyclic carbene as an efficient organic catalyst was employed to catalyze an intramolecular nucleophilic substitution reaction. When R 2 was a phenyl group, the cyclization process underwent isomerization, leading to generation of benzofuranone.

1,4-dihydropyridine derivatives

Compounds a formula (I) STR1 wherein the substituents and symbols have the meanings given in the specification, are new compounds with marked cardiovascular activity.