22042-79-1Relevant articles and documents
Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria
Touitou, Meir,Manetti, Fabrizio,Ribeiro, Camila Maringolo,Pavan, Fernando Rogerio,Scalacci, Nicolò,Zrebna, Katarina,Begum, Neelu,Semenya, Dorothy,Gupta, Antima,Bhakta, Sanjib,Mchugh, Timothy D.,Senderowitz, Hanoch,Kyriazi, Melina,Castagnolo, Daniele
, p. 638 - 644 (2020/01/11)
A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid.
Reactions of 3,5-dimethyl-1-phenyl-1h-pyrazole with electrophiles
Attaryan,Rstakyan,Hasratyan
, p. 1724 - 1727 (2013/02/23)
Reactions of 3,5-dimethyl-1-phenyl-1H-pyrazole with various electrophilic reagents were studied. Electrophilic attack occurred regioselectively at the C4 atom in the pyrazole ring. Pleiades Publishing, Ltd., 2012.
Synthesis of novel linked pyrazolyl-thiazolidinone heterocycles as potent antibacterial agents
Reddy, Cherkupally Sanjeeva,Kumar, Gaddam Rajesh,Devi, MacHerla Vani,Nagaraj, Adki
, p. 576 - 581 (2012/04/18)
A novel series of 2-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-3-(aryl/ heteroaryl)-1,3-thiazolidin-4-one derivatives 4a-h has been synthesized readily in one-pot from 3,5-dimethyl-1-phenyl-1H-4-pyrazolecarbaldehyde (3), and characterized via IR, NMR, MS and elemental analyses. Further, these compounds were screened for antibacterial (MIC) activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Staphylococcus pyogenes. Amongst them, compounds containing pyridyl 4g and pyrimidinyl 4h moiety exerted superior antibacterial activity against S. aureus and E. coli at the concentration of 6.25 μg/mL, which is less than the concentration of the standards neomycin and streptomycin, and emerged as potential molecules for further development.