220455-59-4Relevant articles and documents
Synthesis and transporter binding properties of (R)-2β,3β- and (R)- 2α,3α-diaryltropanes
Jiang, Songchun,Chang, An-Chih,Abraham, Philip,Kuhar, Michael J.,Carroll, F. Ivy
, p. 3689 - 3692 (1998)
(R)-2-Aryl-2-tropinone (9) was synthesized from (R)-2-carbomethoxy-3- tropinone (5) and was used as the key intermediate for the synthesis of (R)- 2β,3β- and (R)-2α-3α-diaryltropanes. Inhibition of radioligand binding studies at the dopamine, serotonin, a
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter
Meltzer, Peter C.,Blundell, Paul,Huang, Hong,Liu, Shanghao,Yong, Yaw F.,Madras, Bertha K.
, p. 581 - 590 (2007/10/03)
The search for medications for cocaine abuse has focused upon the design of potential cocaine antagonists or cocaine substitutes which interact at the dopamine transporter of mammalian systems. This manuscript describes the synthesis and biological evalua