220481-72-1Relevant articles and documents
New bicyclam-AZT conjugates: Design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor
Dessolin, Jean,Galea, Pascale,Vlieghe, Patrick,Chermann, Jean-Claude,Kraus, Jean-Louis
, p. 229 - 241 (2007/10/03)
We report the synthesis of mono- and bis-tetraazamacrocycle-AZT conjugates. All new compounds were screened for their ability to inhibit HIV- 1 replication in MT4 cell line and were compared to AZT alone. It appears that N-protected covalent prodrugs are