220580-85-8

Basic information

• Product Name: 4-iodo-5-phenyloxazole
• Synonyms: 4-iodo-5-phenyloxazole
• CAS NO: 220580-85-8
• Molecular Weight: 271.057
• Mol File: 220580-85-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-iodo-5-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-5-phenyloxazole(220580-85-8)
• EPA Substance Registry System: 4-iodo-5-phenyloxazole(220580-85-8)

Safety Data

• Hazardous Substances Data: 220580-85-8(Hazardous Substances Data)

Upstream product

• 1006-68-4 5-phenyloxazole 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 220580-88-1 2,4-diiodo-5-phenyl-1,3-oxazole 
• 1019654-84-2 5,5'-diphenyl-[2,4']bisoxazole 

Relevant articles and documents

Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping

Oxazoles are rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethylisocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonating Asmic affords a metalated isocyanide that efficiently traps esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent is readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility is illustrated in the three-step synthesis of the bioactive natural product streptochlorin.