22067-29-4

Basic information

• Product Name: Benzaldehyde, (4-phenyl-2-thiazolyl)hydrazone
• CAS NO: 22067-29-4
• Molecular Formula: C16H13N3S
• Molecular Weight: 279.365
• Mol File: 22067-29-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, (4-phenyl-2-thiazolyl)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, (4-phenyl-2-thiazolyl)hydrazone(22067-29-4)
• EPA Substance Registry System: Benzaldehyde, (4-phenyl-2-thiazolyl)hydrazone(22067-29-4)

Safety Data

• Hazardous Substances Data: 22067-29-4(Hazardous Substances Data)

Upstream product

• 1627-73-2 1-benzylidene thiosemicarbazide 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 79-19-6 thiosemicarbazide 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 76767-30-1 benzaldehyde S-allylisothiosemicarbazone 
• 34176-52-8 2-hydrazino-4-phenylthiazole 

Downstream Products

• 73008-53-4 4-(2-benzylidenehydrazino-4-phenyl-thiazol-5-ylazo)-N-carbamoyl-benzenesulfonamide 
• 73008-54-5 4-(2-benzylidenehydrazino-4-phenyl-thiazol-5-ylazo)-N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide 
• 73008-49-8 N-acetyl-4-(2-benzylidenehydrazino-4-phenyl-thiazol-5-ylazo)-benzenesulfonamide 
• 151696-50-3 N-4-phenyl-5-bromo-2-thiazolylbenzohydrazonoyl bromide 
• 26542-64-3 3-phenyl-5-phenylthiazolo-<2,3-c>-s-triazole 
• 119597-27-2 bis-(2-benzylidenehydrazino-4-phenyl-thiazol-5-yl)-(4-nitro-phenyl)-methane 
• 119597-28-3 bis-(2-benzylidenehydrazino-4-phenyl-thiazol-5-yl)-phenyl-methane 
• 114794-82-0 benzylidene-[5-(4-nitro-benzylidene)-4-phenyl-5H-thiazol-2-ylidene]-hydrazine 

Relevant articles and documents

Design, synthesis and biological evaluation of some novel benzylidene-2-(4-phenylthiazol-2-yl) hydrazines as potential anti-inflammatory agents

A series of substituted benzylidene-2-(4-phenylthiazol-2-yl) hydrazines (2a-q) have been synthesized, characterized and evaluated for their anti-inflammatory activity by carrageenin-induced hind paw edema (acute inflammation) and cotton pellet granuloma (chronic inflammation) methods in rats. In carrageenin-induced hind paw edema method, compounds 2a, 2b, 2c, 2d, 2h, 2k and 2p at a dose of 20 mg kg-1 body weight, p.o. showed excellent inhibitions (51.80-86.74 %) in between 1 and 4 h. Similarly, in cotton pellet granuloma method, compounds 2a, 2b, 2c, 2d, 2h, 2k and 2p at a dose of 20 mg kg-1 body weight, p.o. inhibited the granuloma formation (71.71-90.19 % inhibition) which was comparable to that of standard drug, ibuprofen (90.36 % inhibition of paw volume at 3 h and 94.02 % inhibition of granuloma formation). Structure activity relationship studies showed excellent activity of the compounds containing electron withdrawing group (fluoro, chloro, bromo or nitro) in phenyl ring at C2 and/or C4 position of thiazole ring.

Efficient one-pot three-component synthesis of N-(4-arylthiazol-2-yl) hydrazones in water under ultrasound irradiation

A highly efficient and facile one-pot three-component synthesis of N-(4-arylthiazol-2-yl) hydrazones was carried out in excellent yield without any catalyst in water under ultrasound irradiation.

Eco-friendly one-pot synthesis of 2,4-disubstituted thiazoles by grinding under catalyst- and solvent-free conditions

Chemical Equation Presented An efficient and facile synthesis of 2,4-disubstituted thiazoles is achieved by a one-pot reaction of aldehydes and α-bromoketones with thiosemicarbazide by grinding under catalyst- and solvent-free conditions. This method has notable advantages in terms of simple workup, neat conditions, high yield, reasonably rapid reaction rate, and environmental friendliness. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.