22083-74-5Relevant articles and documents
On the biosynthesis of nicotine
Schütte,Maier,Stephan
, p. 1426 - 1429 (1968)
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Alworth et al.
, p. 1608 (1964)
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Leete
, p. 1091 (1972)
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The preparation of tobacco constituents incorporating stable isotopes. I. The synthesis of d,l-nornicotine-1'-15N and d,l-nicotine-11-15N
Edwards III,Glenn,Green,Newman
, p. 255 - 261,259,260 (1978)
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Preparation method of artificially synthesized (R, S)-nicotine salt
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Paragraph 0050; 0054-0055; 0064-0066; 0070-0072; 0075-0077, (2021/06/02)
The invention discloses a preparation method of artificially synthesized (R, S)-nicotine salt. The method comprises: S1, taking 4-methylamino-1-(3-pyridine)-butanone hydrochloride and an alkaline substance, and carrying out a reaction at a temperature of -5-5 DEG C; S2, concentrating a reactant in the step S1, and adding a first refining solvent for refining, so as to obtain 1-methyl-2-(3-pyridine)-2-pyrrolidinol; S3, taking 1-methyl-2-(3-pyridine)-2-pyrrolidinol, adding a reducing agent, and carrying out a reaction at the temperature of 15-35 DEG C; and S4, concentrating the reactant in the step S3, adding a second refining solvent for refining, and then adding acid for reaction to obtain the artificially synthesized (R, S)-nicotine salt. The invention innovatively provides a two-step method for synthesizing the (R, S)-nicotine salt, and the prepared (R, S)-nicotine salt does not contain any other harmful tobacco compounds, has the advantages of simple process and high purity, and is suitable for industrial large-scale production.
Synthesis method of (R, S-) nicotine
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Paragraph 0046-0047, (2021/05/05)
The invention belongs to the technical field of medical intermediates, and particularly relates to a synthesis method of (R, S-) nicotine. The method comprises the following steps: (1) taking methyl nicotinate and N-butenyl pyrrolidone as raw materials, and preparing N-butenyl-3-benzoyl-1-pyrrolidone through a condensation reaction; (2) after the reaction is finished, carrying out hydrolysis reaction, cooling, adjusting the pH value to be alkaline, extracting, separating out an organic phase, concentrating and distilling to obtain an enamine intermediate; and (3) carrying out a reduction reaction on the enamine intermediate under illumination with the wavelength of 200-400nm by using a metal oxide or a complex as a reduction catalyst to obtain the target product (R, S-) nicotine. According to the method, use of the metal catalyst is innovatively proposed, reaction is initiated by illumination with specific wavelength to prepare the (R, S-) nicotine, and the method is simple and convenient to operate, high in yield, low in cost and suitable for industrial large-scale production.
Preparation method of racemic nicotine
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, (2021/10/30)
The invention discloses a preparation method of racemic nicotine. The method comprises the following steps of: preparing methyl nicotinamide from nicotinoyl chloride and methylamine under alkaline conditions; condensing the methyl nicotinamide with monochloroacetone to obtain N-methyl-N-(2-oxypropyl) nicotinamide; carrying out aldol condensation reaction on theN-methyl-N-(2-oxypropyl) nicotinamide to obtain 1-methyl-5-(pyridine-3-yl)-1, 2-dihydro-3H-pyrrole-3-ketone; and finally performing reduction to obtain the racemic nicotine. The invention provides a new route for synthesizing the racemic nicotine; the cheap and easily available nicotinoyl chloride and methylamine are adopted as starting raw materials, so that the cost of the raw materials is low; the whole reaction synthesis route is relatively short, the operation is simple, the reaction condition is mild, the post-treatment is simple; the yield of the synthesized racemic nicotine is high; and the method is suitable for industrial large-scale production.