22098-62-0

Basic information

• Product Name: (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL
• Synonyms: (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL
• CAS NO: 22098-62-0
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 22098-62-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 444.1 °C at 760 mmHg
• Flash Point: 222.4 °C
• Appearance: /
• Density: 1.256 g/cm³
• CAS DataBase Reference: (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL(22098-62-0)
• EPA Substance Registry System: (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL(22098-62-0)

Safety Data

• Hazardous Substances Data: 22098-62-0(Hazardous Substances Data)

Usage

General Description

"(1H-IMIDAZOL-2-YL)-PHENYL-METHANOL" is a chemical compound with a molecular structure containing an imidazole ring fused to a phenyl ring, attached to a methanol group. (1H-IMIDAZOL-2-YL)-PHENYL-METHANOL may have applications in pharmaceuticals, as imidazole-containing compounds are known to have diverse biological activities, including antifungal, antibacterial, and anti-inflammatory properties. The phenyl group may also contribute to the compound's potential as a building block for new drug candidates or other chemical products. Additionally, the presence of the methanol group could make it useful in organic synthesis reactions, as methanol is a common solvent and reactant in chemical processes. Overall, "(1H-IMIDAZOL-2-YL)-PHENYL-METHANOL" has potential as a versatile chemical with a range of applications in drug development and organic chemistry.

Upstream product

• 38353-02-5 2-benzoylimidazole 
• 76100-32-8 2-Benzylimidazol-4,5-dicarbonsaeure 
• 100-52-7 benzaldehyde 
• 61278-81-7 1-(diethoxymethyl)-1H-imidazole 

Relevant articles and documents

1,2-functionalized imidazoles as palladium ligands: An efficient and robust catalytic system for the fluorine-free Hiyama reaction

A variety of hydroxy- and amino-functionalized imidazoles were prepared from 1-methyl- and 1-(diethoxymethyl)imidazole by means of isoprene-mediated lithiation followed by reaction with an electrophile. These compounds in combination with palladium acetate were screened as catalyst systems for the Hiyama reaction under fluorine-free conditions using microwave irradiation. The systematic study of the catalytic system showed 1-methyl-2-aminoalkylimidazole derivative L1 to be the best ligand, which was employed un-der solvent-free conditions with a 1:2 Pd/ligand ratio and TBAB (20 mol-%) as additive. The study has revealed an interaction between the Pd/ligand ratio and the amount of TBAB. The established catalytic system presented a certain degree of robustness, and it has been successfully employed in the coupling of a range of aryl bromides and chlorides with different aryl siloxanes. Furthermore, both reagents were employed in an equimolecular amount, without an excess of organosilane.

Isoprene-catalysed lithiation: deprotection and functionalisation of imidazole derivatives

The isoprene-catalysed lithiation of different 1-substituted imidazoles (1) (such as trityl, allyl, benzyl, vinyl, N,N-dimethylsulfamoyl, para-toluenesulfonyl, tert-butoxycarbonyl, acetyl, trimethylsilyl, tert-butyldimethylsilyl derivatives) leads to the