221006-63-9 Usage
Description
Methyl 3-borono-4-methoxybenzoate is an organic compound that serves as an intermediate in the synthesis of biarylpropionic acid derivatives. It is characterized by the presence of a boron atom and a methoxy group attached to a benzene ring, which contributes to its unique chemical properties and reactivity.
Used in Pharmaceutical Industry:
Methyl 3-borono-4-methoxybenzoate is used as a precursor in the synthesis of biarylpropionic acid derivatives, which are known as cathepsin A inhibitors. These inhibitors have potential applications in the development of pharmaceuticals for the treatment of various diseases and conditions. The boron-containing structure of Methyl 3-borono-4-methoxybenzoate plays a crucial role in the formation of the desired biarylpropionic acid derivatives, making it an essential component in the synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 221006-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,0,0 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 221006-63:
(8*2)+(7*2)+(6*1)+(5*0)+(4*0)+(3*6)+(2*6)+(1*3)=69
69 % 10 = 9
So 221006-63-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BO5/c1-14-8-4-3-6(9(11)15-2)5-7(8)10(12)13/h3-5,12-13H,1-2H3
221006-63-9Relevant articles and documents
Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes
Yu, Congjun,?zkaya, Bünyamin,Patureau, Frederic W.
supporting information, p. 3682 - 3687 (2021/02/01)
A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.
