221121-48-8Relevant articles and documents
Synthesis and biological evaluation of 6-substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
Yu, Mingyan,Li, Zhenyu,Liu, Shuai,Fan, Erkang,Pannecouque, Christophe,DeClercq, Erik,Liu, Xinyong
experimental part, p. 826 - 833 (2012/01/14)
A series of new 5-alkyl-2-phenylaminocarbonylmethylthiopyrimidin-4(3H)-ones bearing variously substituted arylmethyl moieties at the C6 position of the pyrimidine ring were synthesized and evaluated for anti-HIV activity in MT-4 cells. Most of these new c
5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile
Nawrozkij, Maxim B.,Rotili, Dante,Tarantino, Domenico,Botta, Giorgia,Eremiychuk, Alexandre S.,Musmuca, Ira,Ragno, Rino,Samuele, Alberta,Zanoli, Samantha,Armand-Ugón, Mercedes,Clotet-Codina, Imma,Novakov, Ivan A.,Orlinson, Boris S.,Maga, Giovanni,Esté, José A.,Artico, Marino,Mai, Antonello
experimental part, p. 4641 - 4652 (2009/07/04)
A series of dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) bearing a 2-aryl-2-oxoethylsulfanyl chain at pyrimidine C2, an alkyl group at C5, and a 2,6-dichloro-, 2-chloro-6-fluoro-, and 2,6-difluoro-benzyl substitution at C6 (oxophenethyl-S-DABOs, 6-8)
Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: Synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants
Mugnaini, Claudia,Alongi, Maddalena,Togninelli, Andrea,Gevariya, Harsukh,Brizzi, Antonella,Manetti, Fabrizio,Bernardini, Cesare,Angeli, Lucilla,Tafi, Andrea,Bellucci, Luca,Corelli, Federico,Massa, Silvio,Maga, Giovanni,Samuele, Alberta,Facchini, Marcella,Clotet-Codina, Imma,Armand-Ugón, Mercedes,Esté, José A.,Botta, Maurizio
, p. 6580 - 6595 (2008/04/12)
A series of novel S-DABO analogues, characterized by different substitution patterns at positions 2, 5, and 6 of the heterocyclic ring, were synthesized in a straightforward fashion by means of parallel synthesis and evaluated as inhibitors of human immun