22114-45-0Relevant articles and documents
Cooperative Effects Between Arginine and Glutamic Acid in the Amino Acid-Catalyzed Aldol Reaction
Valero, Guillem,Moyano, Albert
, p. 599 - 605 (2016)
Catalysis of the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde by mixtures of L-Arg and of L-Glu in wet dimethyl sulfoxide (DMSO) takes place with higher enantioselectivity (up to a 7-fold enhancement in the anti-aldol for the 1:1 mixture)
Synthesis of hexahydrophenanthridines via the tandem reaction of benzynes
Li, Wen-Juan,Pian, Ji-Xin,Gu, Cheng-Zhi,Dai, Bin,He, Lin
, (2020/07/24)
A tandem insertion-cyclization reaction between carbocyclic β–amino ketones and benzynes has been described, producing hexahydrophenanthridines in moderate to high yields.
Synthesis and Cytotoxic Evaluation of Novel 1,2,3-Triazole-4-Linked (2E,6E)-2-Benzylidene-6-(4-nitrobenzylidene)cyclohexanones
Mahdavi, Mohammad,Akhbari, Maryam,Saeedi, Mina,Karimi, Maryam,Foroughi, Niloufar,Karimpour-Razkenari, Elahe,Alinezhad, Heshmatollah,Foroumadi, Alireza,Shafiee, Abbas,Akbarzadeh, Tahmineh
, p. 175 - 180 (2016/04/19)
This work describes the synthesis of novel 1,2,3-triazole-4-linked (2E,6E)-2-benzylidene-6-(4-nitrobenzylidene)cyclo-hexanones starting from cyclohexanone. 1-(Cyclohex-1-en-1-yl)piperidine, the enamine from cyclohexanone and piperidine, reacted with 4-nitrobenzaldehyde to obtain 2-(4-nitrobenzylidene)cyclohexanone. Condensation of the latter compound with (prop-2-yn-1-yloxy)benzaldehyde derivatives under acidic conditions gave (4-nitrobenzylidene)-[(prop-2-yn-1-yloxy)-benzylidene]cyclohexanones. Finally, 'click reaction' of these derivatives and various organic azides led to the title compounds. All compounds were examined by MTT assay for cytotoxic activity in one human breast cancer cell line, MDA-MB-231.