22117-90-4Relevant articles and documents
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators
Dei, Silvia,Budriesi, Roberta,Sudwan, Paiwan,Ferraroni, Marta,Chiarini, Alberto,Garnier-Suillerot, Arlette,Manetti, Dina,Martelli, Cecilia,Scapecchi, Serena,Teodori, Elisabetta
, p. 985 - 998 (2007/10/03)
A series of compounds with a diphenylmethyl cyclohexyl skeleton, loosely related to verapamil, has been synthesized and tested as MDR modulators on anthracycline-resistant erythroleukemia K 562 cells. Their residual cardiovascular action (negative inotrop
α-Amino Carbanions. Preparation, Metalation, and Alkylation of Enamidines. Synthesis of Piperidine and Pyrrolidine Natural Products and Homologation of Carbonyl Compounds
Meyers, A. I.,Edwards, Philip D.,Bailey, Thomas R.,Jagdmann, G. Erik
, p. 1019 - 1026 (2007/10/02)
Saturated heterocycles, as their tert-butylformamidines, may be transformed into enamidines, by metalation-selenation-elimination.These enamidines are valuable precursors to 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted pyrrolidines, piperidines, and perhydroazepines, prepared in a regiospecific manner.The method is demonstrated by the synthsesis of selenopsin A and the red fire ant venom.The use of acyclic enamidines is displayed as a homologation reagent which converts carbonyl compounds to higher alkyl derivatives.
Enamidines. Versatile Vehicles for Homologation of Carbonyl Compounds
Meyers, A. I.,Jagdmann, G. Erik
, p. 877 - 879 (2007/10/02)
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