2212-69-3

Basic information

• Product Name: Z-LYS(BOC)-ONP
• Synonyms: N-ALPHA-BENZYLOXYCARBONYL-N-EPSILON-BOC-L-LYSINE 4-NITROPHENYL ESTER;N-ALPHA-BENZYLOXYCARBONYL-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE P-NITROPHENYL ESTER;N-ALPHA-Z-N-EPSILON-BOC-L-LYSINE4-NITROPHENYL ESTER;Z-N-EPSILON-BOC-L-LYSINE 4-NITROPHENYL ESTER;Z-N-EPSILON-BOC-L-LYSINE P-NITROPHENYL ESTER;Z-LYS(BOC)-ONP;Z-LYSINE(BOC)-ONP;N-EPSILON-T-BOC-NA-CBZ-L-LYSINE P-*NITROPHENYL ESTER
• CAS NO: 2212-69-3
• Molecular Formula: C₂₅H₃₁N₃O₈
• Molecular Weight: 501.53
• Product Categories: Amino Acid Derivatives
• Mol File: 2212-69-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 93.5-94.5 °C
• Boiling Point: 676.9 °C at 760 mmHg
• Flash Point: 363.2 °C
• Appearance: /Solid
• Density: 1.234g/cm³
• Vapor Pressure: 3.5E-18mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• PKA: 10.61±0.46(Predicted)
• CAS DataBase Reference: Z-LYS(BOC)-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LYS(BOC)-ONP(2212-69-3)
• EPA Substance Registry System: Z-LYS(BOC)-ONP(2212-69-3)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 2212-69-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C25H31N3O8/c1-25(2,3)36-23(30)26-16-8-7-11-21(27-24(31)34-17-18-9-5-4-6-10-18)22(29)35-20-14-12-19(13-15-20)28(32)33/h4-6,9-10,12-15,21H,7-8,11,16-17H2,1-3H3,(H,26,30)(H,27,31)

Upstream product

• 2389-60-8 Z-Lys(Boc)-OH 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 25887-81-4 bis(p-nitrophenyl)sulfite 
• 2212-76-2 N^α-benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 4583-23-7 Z-L-Lys(BOC)-L-Pro-OH 
• 1202657-36-0 methyl 3-(Nα-benzyloxycarbonyl-Nε-tert-butoxycarbonyl-L-lysyl-Nε-tert-butoxycarbonyl-L-lysylamino)-1H-pyrazole-5-carboxylate 
• 1202657-35-9 methyl 3-(Nα-benzyloxycarbonyl-Nε-tert-butoxycarbonyl-L-lysylamino)-1H-pyrazole-5-carboxylate 
• 1019330-67-6 C₃₃H₄₆N₃O₉P 
• 14551-00-9 N^α-Benzyloxycarbonyl-N^ε-tert.-butoxycarbonyl-Lys-Phe-hydrazid 
• 47689-13-4 N-(N^α-carbobenzoxy-N^ε-tert-butoxycarbonyl-L-lysyl)glycine 
• 128404-15-9 N-benzyloxycarbonylglycyl-N^ε-tert-butyloxycarbonyl-lysyl-seryl-glutamyl-glycylglycine benzylester 
• 128404-16-0 {2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester 
• 128404-13-7 N-benzyloxycarbonyl-glycyl-N^ε-tert-butyloxycarbonyl-lysyl-serine 
• 78432-02-7 Benzyloxycarbonylthreonyl(ε-tert-butoxycarbonyllysyl)prolylarginine 
• 9063-57-4 thr-Lys-Pro-Arg 
• 80220-25-3 Z-Ile-Arg(Mds)-Pro-Lys(Boc)-Leu-Lys(Boc)-OBut 
• 401942-23-2 C₄₈H₇₄N₁₀O₁₈ 
• 401942-22-1 ZThrLys(Boc)ProThrAspGlyAsnOH 

Relevant articles and documents

SULFOXONIUM YLIDE DERIVATIVES AS PROBES FOR CYSTEINE PROTEASE

The present invention relates to compounds of formula I bearing a sulfoxonium ylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.

Use of the 4-methoxy-2,6-dimethylbenzenesulfonyl (Mds) group to synthesize dynorphin [1-13] and related peptides

-