22122-89-0

Basic information

• Product Name: 6-PHENYL-4-(TRIFLUOROMETHYL)-2-PYRIDONE
• Synonyms: 4-(TRIFLUOROMETHYL)-6-PHENYLPYRIDIN-2(1H)-ONE;6-PHENYL-4-(TRIFLUOROMETHYL)-2-PYRIDONE
• CAS NO: 22122-89-0
• Molecular Formula: C₁₂H₈F₃NO
• Molecular Weight: 239.19
• Mol File: 22122-89-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-PHENYL-4-(TRIFLUOROMETHYL)-2-PYRIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENYL-4-(TRIFLUOROMETHYL)-2-PYRIDONE(22122-89-0)
• EPA Substance Registry System: 6-PHENYL-4-(TRIFLUOROMETHYL)-2-PYRIDONE(22122-89-0)

Safety Data

• Hazardous Substances Data: 22122-89-0(Hazardous Substances Data)

Upstream product

• 49639-34-1 phenylsulfinylacetic acid amide 
• 114192-88-0 (E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one 
• 25597-16-4 ethyl 4,4,4-trifluorobut-2-enoate 
• 19433-17-1 acetophenone O-acetyloxime 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 3335-44-2 2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 136964-14-2 (Z)-1-phenyl-4,4,4-trifluoro-2-buten-1-one 
• 3108-34-7 (E)-4,4,4-trifluoro-1-phenyl-2-buten-1-one 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Synthesis of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives and their anticancer activity

A series of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives 6a-n were prepared starting from 2(1H) pyridone 1 via hydrolysis, de-carboxylation, selective O-alkylation followed by rearrangement to give pyridine-2-amine 3. Compound 3 on reaction wit

One-Pot Sequential Multistep Transformation of α,β-Unsaturated Trifluoromethyl Ketones: Facile Synthesis of Trifluoromethylated 2-Pyridones

A one-pot transformation of α,β-unsaturated trifluoromethyl ketones with 2-(phenylsulfinyl)acetamide to give trifluoromethylated 2-pyridones is realized. The reaction proceeds under mild conditions and involves multiple steps in an expeditious and controlled sequence to provide efficient access to a broad range of trifluoromethylated 2-pyridones in moderate to high yields. Moreover, further synthetic manipulations permit the routine synthesis of a diverse array of trifluoromethylated pyridines with good efficiency.