221243-01-2

Basic information

• Product Name: HOMO-L-TYROSINE HBR
• Synonyms: L-HOMOTYROSINE HYDROBROMIDE SALT;H-TYR(NO CH2)-OH HBR;HOMO-TYROSINE HBR;HOMO-TYROSINE HYDROBROMIDE;HOMO-L-TYROSINE HBR;HOMO-L-TYROSINE, HYDROBROMIDE;H-HTY-OH HBR;H-HTYR-OH HBR
• CAS NO: 221243-01-2
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 276.13
• Mol File: 221243-01-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 217-220 °C
• Boiling Point: 397°Cat760mmHg
• Flash Point: 193.9°C
• Appearance: /
• Density: 1.281g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.30±0.10(Predicted)
• CAS DataBase Reference: HOMO-L-TYROSINE HBR(CAS DataBase Reference)
• NIST Chemistry Reference: HOMO-L-TYROSINE HBR(221243-01-2)
• EPA Substance Registry System: HOMO-L-TYROSINE HBR(221243-01-2)

Safety Data

• Hazardous Substances Data: 221243-01-2(Hazardous Substances Data)

Usage

General Description

HOMO-L-Tyrosine HBr is a modified variant of the amino acid Tyrosine. It is composed of hydrogen, bromine, carbon, nitrogen, and oxygen. As a biochemical, it's often used in scientific research, including studies related to protein synthesis, neurological function, and cellular communication. It is soluble in water, making it suitable for use in various lab and experimental contexts. Like Tyrosine, it can play a role in the production of certain neurotransmitters and hormones, however, its altered structure may affect how it functions in biological systems. For safety, it should be handled with care, avoiding eye and skin contact.

Upstream product

• 82311-00-0 O-methyl-L-homotyrosine 
• 82267-44-5 DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid 
• 82267-39-8 diethyl<2-(p-methoxyphenyl)ethyl>(acetamido)malonate 
• 14425-64-0 4-methoxyphenethyl bromide 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 108-95-2 phenol 
• 1263096-03-2 C₁₃H₁₄F₃NO₄ 
• 1263095-99-3 C₁₃H₁₂F₃NO₅ 
• 1207162-70-6 tiglicamide A 
• 1110667-86-1 cyanopeptolin 880 
• 620600-60-4 methanesulfonic acid 2-[4-(tert-butyl-dimethyl-silyloxy)-phenyl]-ethyl ester 
• 185063-17-6 2-(4’-t-butyldimethylsilyloxyphenyl)-1-iodoethane 
• 96013-75-1 2-(4{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol 
• 501-94-0 p-hydroxyphenethyl alcohol 

Downstream Products

• 296774-51-1 L-homotyrosine methyl ester 
• 198560-10-0 Fmoc-hTyrOH 
• 296774-60-2 4-(4-benzyloxycarbonylamino-phenyl)-2-tert-butoxycarbonylamino-butyric acid methyl ester 
• 296774-61-3 L-N^α-(tert-butoxycarbonyl)-4-(N-benzyloxycarbonylamino)-homophenylalanine 
• 296774-53-3 4-(3-tert-butoxycarbonylamino-3-methoxycarbonyl-propyl)-benzoic acid 
• 296774-54-4 Boc-hTyr(CH₂OH)OMe 
• 296774-55-5 Boc-hTyr(CH₂OH)OH 
• 296774-52-2 Boc-hTyrOMe 
• 185063-20-1 nitroveratryloxycarbonyl-4-nitroveratryl-homotyrosine methyl ester 
• 185063-19-8 nitroveratryloxycarbonyl-homotyrosine methyl ester 
• 551929-86-3 [26-azido-6-{2-[3-(2-benzyloxycarbonylamino-acetylamino)-4-hydroxy-phenyl]-ethyl}-11-hydroxy-3,15-bis-(1-hydroxy-ethyl)-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaaza-tricyclo[22.3.0.0^9,13]heptacos-18-yl]-carbamic acid tert-butyl ester 
• 551929-85-2 (2S,4S)-4-Azido-1-{(2S,3R)-2-[(S)-4-[3-(2-benzyloxycarbonylamino-acetylamino)-4-hydroxy-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-3-hydroxy-butyryl}-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Method for Preparing Unnatural Amino Acids

The present invention relates to a manufacturing method of unnatural amino acids and unnatural amino acids manufactured thereby. Specifically, the present invention relates to an asymmetric synthesis method which can manufacture unnatural amino acids having significantly high optical purity, and to the unnatural amino acids manufactured thereby. A manufacturing method of unnatural amino acids represented by chemical formula 6 or chemical formula 7 comprises the steps of: synthesizing a compound represented by chemical formula 4 or chemical formula 5; manufacturing a diol compound; and manufacturing a carboxylic acid compound.COPYRIGHT KIPO 2016

Comparisons of O-acylation and Friedel-Crafts acylation of phenols and acyl chlorides and Fries rearrangement of phenyl esters in trifluoromethanesulfonic acid: Effective synthesis of optically active homotyrosines

Reactions involving phenol derivatives and acyl chlorides have to be controlled for competitive O-acylations and C-acylations (Friedel-Crafts acylations and Fries rearrangements) in acidic condition. The extent for these reactions in trifluoromethanesulfonic acid (TfOH), which is used as catalyst and solvent, is examined. Although diluted TfOH was needed for effective O-acylation, concentrated TfOH was required for effective C-acylations in mild condition. These results have been applied to the novel synthesis of homotyrosine derivatives. Both Fries rearrangement of N-TFA-Asp(OBn)-OMe and Friedel-Crafts acylation of phenol with N-TFA-Asp(Cl)-OMe in TfOH afforded the homotyrosine skeleton, followed by reduction and deprotection afforded homotyrosines maintaining stereochemistry of Asp as an optically pure form.

Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8

Two homotyrosine-bearing cyanopeptolins are described from Planktothrix agardhii CYA 126/8. The compounds feature a common homotyrosine-containing cyclohexadepsipeptide and differ by sulfation of an exocyclically located 2-O-methyl-D-glyceric acid residue. In addition we describe two anabaenopeptins, which contain two homotyrosine residues, one of which is N-methylated. The anabaenopeptins have a common cyclopentapeptide portion and differ in the amino acid linked to it via an ureido bond, arginine and tyrosine, respectively.