221298-75-5

Basic information

• Product Name: 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE
• Synonyms: 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE
• CAS NO: 221298-75-5
• Molecular Formula: C9H6BrClN2
• Molecular Weight: 257.51434
• EINECS: 200-589-5
• Mol File: 221298-75-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE(221298-75-5)
• EPA Substance Registry System: 8-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE(221298-75-5)

Safety Data

• Hazardous Substances Data: 221298-75-5(Hazardous Substances Data)

Upstream product

• 20780-74-9 7-bromoisatin 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 104670-74-8 methyl 2-amino-3-bromobenzoate 
• 71478-56-3 8-bromo-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 615-36-1 2-bromoaniline 
• 101080-38-0 N-(2-bromophenyl)-2-isonitrosoacetanilide 

Downstream Products

• 1268520-96-2 C₁₀H₉N₃O₂ 

Relevant articles and documents

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Intra-molecular hydrogen bonding was introduced to the quinazoline motif to form a pseudo ring (intra-molecular H-bond scaffold, iMHBS) to mimic our previous published core structures, pyrido[2.3-D]pyrimidin-7-one and pteridinone, as PI3K/mTOR dual inhibitors. This design results in potent PI3K/mTOR dual inhibitors and the purposed intra-molecular hydrogen bonding structure is well supported by co-crystal structure in PI3Kγ enzyme. In addition, a novel synthetic route was developed for these analogs.