221311-44-0 Usage
Description
2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde is an organic compound characterized by its unique chemical structure, which features a benzoxazine ring fused with a carbaldehyde group. 2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde has garnered interest in the scientific community due to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde is used as a poly(ADP-ribose)polymerase (PARP) inhibitor for its potential therapeutic applications in cancer treatment. PARP inhibitors are a class of drugs that have shown promise in treating various types of cancer by exploiting the DNA repair deficiencies in cancer cells, leading to their selective destruction.
The compound's ability to inhibit PARP enzymes can be utilized in the development of novel therapeutic strategies targeting cancer cells with impaired DNA repair mechanisms, such as those with BRCA mutations. This selective toxicity can provide a more targeted approach to cancer treatment, potentially reducing side effects and improving patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 221311-44-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,3,1 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 221311-44:
(8*2)+(7*2)+(6*1)+(5*3)+(4*1)+(3*1)+(2*4)+(1*4)=70
70 % 10 = 0
So 221311-44-0 is a valid CAS Registry Number.
221311-44-0Relevant articles and documents
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors
Gangloff, Anthony R.,Brown, Jason,De Jong, Ron,Dougan, Douglas R.,Grimshaw, Charles E.,Hixon, Mark,Jennings, Andy,Kamran, Ruhi,Kiryanov, Andre,O'Connell, Shawn,Taylor, Ewan,Vu, Phong
, p. 4501 - 4505 (2013/08/15)
Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.
Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals
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Example 1, (2010/01/31)
Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.
