221348-21-6

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-
• CAS NO: 221348-21-6
• Molecular Formula: C15H11FN2O2
• Molecular Weight: 270.263
• Mol File: 221348-21-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-(221348-21-6)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-(221348-21-6)

Safety Data

• Hazardous Substances Data: 221348-21-6(Hazardous Substances Data)

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 925252-30-8 (1Z)-2-(4-fluorophenyl)-N'-hydroxyethanimidamide 
• 22179-78-8 4-fluoro-benzamidoxime 
• 22179-78-8 (Z)-4-fluoro-N'-hydroxybenzimidamide 
• 1194-02-1 4-fluorobenzonitrile 
• 100-07-2 4-methoxy-benzoyl chloride 
• 888264-61-7 C₁₅H₁₃FN₂O₃ 

Downstream Products

• 748771-37-1 4-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-phenol 

Relevant articles and documents

Synthesis method of 3, 5-disubstituted 1, 2, 4-oxadiazole

The invention relates to a novel synthetic method for synthesizing 3, 5-disubstituted-1, 2, 4-oxadiazole, in particular to a synthetic method of 3, 5-disubstituted-1, 2, 4-oxadiazole. The method disclosed by the invention has the characteristics that the reaction is carried out at room temperature, the 1, 2, 4-oxadiazole is synthesized at high yield by a one-pot method, and a final product does not need to be subjected to column chromatography. The 3, 5-disubstituted-1, 2, 4-oxadiazole synthesized by the invention can be used in the field of medical treatment.

Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists

A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In add

Parallel synthesis of 1,2,4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation

We describe the synthesis of 1,2,4-oxadiazoles from carboxylic acids and amidoximes using 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) as an activating agent of the carboxylic acid function for the O-acylation step. This method was used for the synthesis of a library of 24 1,2,4-oxadiazoles.