221377-36-2

Basic information

• Product Name: 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide
• Synonyms: 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide
• CAS NO: 221377-36-2
• Molecular Weight: 565.066
• Mol File: 221377-36-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide(221377-36-2)
• EPA Substance Registry System: 7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indole-3-acetamide(221377-36-2)

Safety Data

• Hazardous Substances Data: 221377-36-2(Hazardous Substances Data)

Upstream product

• 159503-76-1 7-chloro-N,N-dimethyl-1H-indole-3-methanamine 
• 221377-37-3 7-chloro-1H-indole-3-acetonitrile 
• 53924-05-3 7-chloro-1H-indole 
• 145852-85-3 1,5-anhydro-3,6-di-O-benzyl-4-O-methyl-2-deoxy-D-arabino-hex-1-wnopyranose 
• 73945-45-6 7-chloro-1H-indole-3-acetamide 

Downstream Products

• 221377-35-1 3-(1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 
• 221377-34-0 3-(7-chloro-1H-indol-3-yl)-4-<7-chloro-1-<4-O-methyl-3,6-bis-O-(phenymethyl)-β-D-glucopyranosyl>-1H-indol-3-yl>-1H-pyrrole-2,5-dione 

Relevant articles and documents

Synthesis of rebeccamycin and 11-dechlororebeccamycin

Glycosylated 7-chloroindole-3-acetamide 9, prepared in four steps and 26% yield from 7-chloroindole (1), was condensed with methyl 7-chloroindole- 3-glyoxylate 11 and methyl indole-3-glyoxylate 12 to provide bisindolylmaleimides 7 and 8 in 86% and 84% yield, respectively. Oxidation of 7 and 8 followed by debenzylation provided a new approach to the synthesis of rebeccamycin and completed for the first time a synthesis of 11- dechlororebeccamycin.