221381-90-4

Basic information

• Product Name: Benzoic acid, 3-nitro-4-(2-oxo-1-pyrrolidinyl)-, methyl ester
• CAS NO: 221381-90-4
• Molecular Formula: C12H12N2O5
• Molecular Weight: 264.238
• Mol File: 221381-90-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-nitro-4-(2-oxo-1-pyrrolidinyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-nitro-4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-90-4)
• EPA Substance Registry System: Benzoic acid, 3-nitro-4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-90-4)

Safety Data

• Hazardous Substances Data: 221381-90-4(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 36151-44-7 4-(2-oxopyrrolidin-1-yl)benzoic acid 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 221381-89-1 1-(4-methoxycarbonylphenyl)pyrrolidin-2-one 
• 67-56-1 methanol 
• 926192-55-4 3-nitro-4-(2-oxo-pyrrolidin-1-yl)-benzoic acid 

Downstream Products

• 221382-11-2 1-<4-methoxycarbonyl-2-(3-pentylamino)phenyl>pyrrolidin-2-one 
• 221381-92-6 1-<4-methoxycarbonyl-2-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl>pyrrolidin-2-one 
• 234110-57-7 1-{2-{[(Amino)(imino)methyl]amino}-4-carboxyphenyl}pyrrolidin-2-one 
• 221381-91-5 1-(4-methoxycarbonyl-2-aminophenyl)pyrrolidin-2-one 

Relevant articles and documents

Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors

A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.

Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping

A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3- guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.