221526-51-8

Basic information

• Product Name: (4aS,8aS)-2-benzenesulfonyl-8a-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydroisoquinoline-1,6-dione
• Synonyms: (4aS,8aS)-2-benzenesulfonyl-8a-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydroisoquinoline-1,6-dione
• CAS NO: 221526-51-8
• Molecular Weight: 558.676
• Mol File: 221526-51-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4aS,8aS)-2-benzenesulfonyl-8a-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydroisoquinoline-1,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (4aS,8aS)-2-benzenesulfonyl-8a-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydroisoquinoline-1,6-dione(221526-51-8)
• EPA Substance Registry System: (4aS,8aS)-2-benzenesulfonyl-8a-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]methyl-1,2,3,4,4a,5,6,8a-octahydroisoquinoline-1,6-dione(221526-51-8)

Safety Data

• Hazardous Substances Data: 221526-51-8(Hazardous Substances Data)

Upstream product

• 71735-01-8 (E)-3-(tert-butyldimethylsilyloxy)-1-methoxy-1,3-butadiene 
• 221526-77-8 1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-5,6-dihydro-1H-pyridin-2-one 
• 675-20-7 piperidin-2-one 
• 7744-25-4 1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one 
• 98-09-9 benzenesulfonyl chloride 
• 221526-66-5 methyl N-benzenesulfonyl-L-serinate 
• 221526-67-6 methyl (4S)-3-benzenesulfonyl-2,2-dimethyloxazolidine-4-carboxylate 
• 221526-73-4 (RS)-1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-piperidin-2-one 
• 221526-71-2 (RS)-1-benzenesulfonyl-3-[(RS)-[(4S)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-yl]hydroxymethyl]piperidin-2-one 
• 263844-45-7 (RS)-1-benzenesulfonyl-3-[(4R)-3-benzenesulfonyl-2,2-dimethyloxazolidin-4-ylmethyl]-3-phenylthiopiperidin-2-one 
• 221526-69-8 (4S)-3-benzenesulfonyl-4-formyl-2,2-dimethyl-3-oxazolidine 
• 593288-89-2 1-benzenesulfonyl-3-(2R)-2-benzenesulfonylamino-3-hydroxypropyl-1,2,5,6-tetrahydropyridin-2-one 
• 637773-08-1 (S)-3-Benzenesulfonyl-2,2-dimethyl-oxazolidine-4-carboxylic acid 
• 71735-01-8 1-methoxy-[3-(tert-butyldimethylsilyl)oxy]-1,3-butadiene 

Downstream Products

• 221526-54-1 N-((1S,6S,10S,13R)-3-Benzenesulfonyl-2,8-dioxo-11-oxa-3-aza-tricyclo[8.4.0.0^1,6]tetradec-13-yl)-benzenesulfonamide 
• 221526-53-0 (4aS,7aS,9R,10aS)-2,8-Bis-benzenesulfonyl-9-hydroxymethyl-octahydro-pyrrolo[2,3-i]isoquinoline-1,6-dione 
• 221526-59-6 C₄₂H₄₈N₂O₈S₂Si 
• 244074-49-5 3,9-bis-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-3,9-diaza-cyclopenta[d]naphthalene-5,10-dione 
• 221526-60-9 C₃₆H₄₄N₂O₆SSi 
• 221526-61-0 C₃₅H₄₈N₂O₆Si 

Relevant articles and documents

Asymmetric synthesis of hydroisoquinoline derivatives, a key intermediate for manzamine synthesis, by diels-alder reaction using 4-amino-2-siloxybutadiene

A novel method for the synthesisof chiral hydroisoquinolines by asymmetricDiels-Alder reaction of nitrogen-containing dienophiles and suitably protected aminosiloxybutadienes has been developed.

An efficient access to the optically active manzamine tetracyclic ring system

The highly stereoselective synthesis of the optically active tetracyclic core 2 of Manzamine A 1 was achieved via the Diels-Alder reaction of dihydropyridinone 12b, derived from L-serine, with siloxydienes, followed by sequential new and conventional pathways.