22156-48-5

Basic information

• Product Name: 4,4-diphenylbutyronitrile
• Synonyms: 4,4-diphenylbutyronitrile;γ-Phenylbenzenebutanenitrile;Einecs 244-810-4
• CAS NO: 22156-48-5
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.297
• EINECS: 244-810-4
• Mol File: 22156-48-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 375.1°Cat760mmHg
• Flash Point: 194°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 7.98E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 4,4-diphenylbutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-diphenylbutyronitrile(22156-48-5)
• EPA Substance Registry System: 4,4-diphenylbutyronitrile(22156-48-5)

Safety Data

• Hazardous Substances Data: 22156-48-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H15N/c17-13-7-12-16(14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16H,7,12H2

Upstream product

• 530-48-3 1,1-Diphenylethylene 
• 75-64-9 tert-butylamine 
• 85-01-8 phenanthrene 
• 75-31-0 isopropylamine 
• 28098-84-2 1-cyano-2,2-diphenylcyclopropane 
• 19376-56-8 4,4,4-trichloro-butyronitrile 
• 71-43-2 benzene 
• 827-54-3 2-naphthylethylene 
• 98-80-6 phenylboronic acid 
• 104675-46-9 4-methanesulfonyloxy-1,1-diphenylbutane 
• 55124-29-3 diethyl 2-(3',3'-diphenylpropyl)malonate 
• 101790-37-8 2-(3,3-diphenylpropyl)malonic acid 
• 20017-67-8 3,3-diphenylpropan-1-ol 
• 606-83-7 3,3-Diphenylpropionic acid 

Downstream Products

• 222545-59-7 Histaprodifen 
• 638167-96-1 4-(2-chloroethyl)-2-(3,3-diphenylpropyl)-1H-imidazole 
• 1026412-65-6 2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethanol 
• 38151-56-3 4,4-diphenylbutyraldehyde 
• 23434-73-3 5,5-diphenylpentanoic acid 
• 36765-74-9 4,4-Diphenylbutylamine 
• 33885-06-2 butane-1,1,4-triyltribenzene 
• 145533-02-4 N-(4,4-diphenylbutyl)-2-phenylethylamine 

Relevant articles and documents

Copper-Catalyzed Radical Cross-Coupling of Redox-Active Oxime Esters, Styrenes, and Boronic Acids

A visible-light-driven, copper-catalyzed three-component radical cross-coupling of oxime esters, styrenes, and boronic acids has been developed. Key steps of this protocol involve catalytic generation of an iminyl radical from a redox-active oxime ester and subsequent C?C bond cleavage to generate a cyanoalkyl radical. Upon its addition to styrene, the newly formed benzylic radical undergoes coupling with a boronic-acid-derived ArCuII complex to achieve 1,1-diarylmethane-containing alkylnitriles.

Controlling the photochemical reactions of alkenes by light-path length effects of a microchannel reactor

Photoirradiation of Me2CO-H2O solution of pent-4-en-1-ol (1a) with a high-pressure mercury lamp in a test tube gave 8-hydroxyoctan-2-one (3a) in 66 % yield along with oxetane (4a) and the isomer (4a') in 10 % yield. Irradiation of the running Me2CO-H2O solution of 1a in the flow system of a microchannel reactor (MCR) gave mainly 4a. The photoreaction of 1,1-diphenylethene (2a) with triethylamine gave a Markovnikov-type adduct (5a) and an anti-Markovnikov-type adduct (6a). The use of the MCR enhanced the production of 5a. These phenomena were explained by the light-path length effects of the MCR.

CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS

A compound of the formula: wherein R 1 and R 2 each represents hydrogen, lower alkyl which may be substituted or acyl; R 3, R 4 and R 5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R 4 and R 5 taken together represent a 5-or 6-membered carbocyclic group; R 6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5-to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH 2, COCH 2, OCH 2, SCH 2, NHCH 2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.