221664-06-8

Basic information

• Product Name: 6-ethoxy-N-<1-(3,4-dimethoxyphenyl)-2-methoxycarbonylethyl>piperidin-2-one
• CAS NO: 221664-06-8
• Molecular Weight: 365.426
• Mol File: 221664-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-ethoxy-N-<1-(3,4-dimethoxyphenyl)-2-methoxycarbonylethyl>piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethoxy-N-<1-(3,4-dimethoxyphenyl)-2-methoxycarbonylethyl>piperidin-2-one(221664-06-8)
• EPA Substance Registry System: 6-ethoxy-N-<1-(3,4-dimethoxyphenyl)-2-methoxycarbonylethyl>piperidin-2-one(221664-06-8)

Safety Data

• Hazardous Substances Data: 221664-06-8(Hazardous Substances Data)

Upstream product

• 167887-40-3 methyl (3S)-3-amino-3-(3,4-dimethoxyphenyl)propanoate 
• 5396-64-5 methyl (E)-3-(3,4-dimethoxyphenyl)acrylate 
• 108-55-4 glutaric anhydride, 
• 64-17-5 ethanol 
• 221664-07-9 (S)-N-<1-(3,4-dimethoxyphenyl)-2-methoxycarbonylethyl>glutarimide 

Downstream Products

• 221664-08-0 (6S,9aR)-6-(3,4-Dimethoxy-phenyl)-8-methylene-octahydro-quinolizin-4-one 

Relevant articles and documents

Asymmetric synthesis of quinolizidine alkaloids (-)-lasubine I, (-)- lasubine II and (+)-subcosine II

The enantioselective synthesis of (-)-lasubine I 1 and the first asymmetric synthesis of (-)-lasubine II 2 and (+)-subcosine II 3 is described. The key step is the intramolecular cyclization of N-acyliminium ion 4 which is derived from (S)-aminoester 6.