221675-35-0

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester;Ethyl 7-azaindole-2-carboxylate;1H-Prrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester;2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine;ethyl 1H-pyrrolo[2,3-b]pyridine-2-carbo×ylate;ethyl 1H-pyrrolo[2;ethyl1H-pyrrolo[2,3-b]pyridine-2-carbo;2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine, Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• CAS NO: 221675-35-0
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Product Categories: Heterocycle-Pyridine series
• Mol File: 221675-35-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 355.936 °C at 760 mmHg
• Flash Point: 169.064 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.73±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester(221675-35-0)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester(221675-35-0)

Safety Data

• Hazardous Substances Data: 221675-35-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester is a chemical compound with a molecular formula C11H11NO2. It is an ester derived from the carboxylic acid of 1H-Pyrrolo[2,3-b]pyridine-2,3-d, and it is commonly used in organic synthesis and pharmaceutical research. 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester has potential applications in various fields, including medicinal chemistry and drug development. It is important to handle this chemical with care and follow proper safety protocols when working with it in a laboratory setting.

InChI:InChI=1/C10H10N2O2/c1-2-14-10(13)8-6-7-4-3-5-11-9(7)12-8/h3-6H,2H2,1H3,(H,11,12)

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 109-04-6 2-bromo-pyridine 
• 105-56-6 ethyl 2-cyanoacetate 
• 108-99-6 3-Methylpyridine 
• 64-17-5 ethanol 
• 136818-50-3 7-azaindole-2-carboxylic acid 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 189089-90-5 1-(phenyl-sulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 271-63-6 7-Azaindole 
• 287384-79-6 1-(tert-butyl) 2-ethyl 2-hydroxy-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 95-92-1 oxalic acid diethyl ester 
• 1205747-95-0 Ethyl 3-{2-[(tert-butoxycarbonyl)amino]-3-pyridyl}-2-oxopropanoate 

Downstream Products

• 920978-89-8 ethyl 1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 
• 172648-34-9 ethyl 1-methyl-7-azaindole-2-carboxylate 
• 1198416-38-4 C₁₀H₁₀N₂O₂ 
• 1272003-73-2 C₁₅H₉N₃O₂ 
• 1407189-77-8 C₁₉H₁₈F₃N₃O₂ 
• 1234616-71-7 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 942920-55-0 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 1352805-43-6 N-methoxy-N-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide 
• 136818-50-3 7-azaindole-2-carboxylic acid 
• 287384-82-1 ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide 

Relevant articles and documents

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Herein we report the discovery and SAR of an indole-based protease activated receptor-4 (PAR-4) antagonist scaffold derived from a similarity search of the Vanderbilt HTS collection, leading to MLPCN probe ML354 (VU0099704). Using a novel PAC-1 fluorescent αIIbβ3 activation assay this probe molecule antagonist was found to have an IC50of 140 nM for PAR-4 with 71-fold selectivity versus PAR-1 (PAR-1IC50= 10 μM).

HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS

Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

From four molecules, inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) an