2219-82-1

Basic information

• Product Name: 2-tert-Butyl-6-methylphenol
• Synonyms: 6-TERT-BUTYL-2-METHYLPHENOL;6-TERT-BUTYL-O-CRESOL;6-TERT-BUTYL ORTHO-CRESOL;2-METHYL-6-TERT-BUTYLPHENOL;2-TERT-BUTYL-6-METHYLPHENOL;2-(1,1-Dimethylethyl)-6-methylphenol;2-(1,1-dimethylethyl)-6-methyl-pheno;2-tert-butyl-6-methyl-pheno
• CAS NO: 2219-82-1
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.24
• EINECS: 218-734-7
• Product Categories: Industrial/Fine Chemicals
• Mol File: 2219-82-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 24-27 °C(lit.)
• Boiling Point: 230 °C(lit.)
• Flash Point: 225 °F
• Appearance: /
• Density: 0.967 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0532mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.69±0.10(Predicted)
• Water Solubility: Insoluble in water
• BRN: 1862362
• CAS DataBase Reference: 2-tert-Butyl-6-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butyl-6-methylphenol(2219-82-1)
• EPA Substance Registry System: 2-tert-Butyl-6-methylphenol(2219-82-1)

Safety Data

• Hazard Codes: C
• Statements: 34-37
• Safety Statements: 26-28-36/37/39-45
• RIDADR: UN 2430 8/PG 1
• WGK Germany: 3
• RTECS: SK1578200
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2219-82-1(Hazardous Substances Data)

Usage

Description

2-tert-Butyl-6-methylphenol, also known as 6-tert-Butyl-o-cresol, is a crystalline solid with a light straw color. It is soluble in various organic solvents such as methyl ethyl ketone, ethanol, benzene, and isooctane, but it is insoluble in water. 2-tert-Butyl-6-methylphenol is combustible and is widely used in different industries due to its antioxidant properties and versatility as a chemical intermediate.

Uses

Used in Plastic Industry:
2-tert-Butyl-6-methylphenol is used as an antioxidant in the preparation method of insulating polyamide special injection plastic for transformers. Its antioxidant properties help to prevent the degradation of the plastic material, ensuring the longevity and performance of the transformers.
Used as a Chemical Intermediate:
In the chemical industry, 2-tert-Butyl-6-methylphenol serves as a crucial intermediate in the synthesis of various compounds and materials. Its unique structure and reactivity make it a valuable building block for creating a range of products, from pharmaceuticals to specialty chemicals.

InChI:InChI=1/C11H16O/c1-8-6-5-7-9(10(8)12)11(2,3)4/h5-7,12H,1-4H3

Upstream product

• 616-55-7 2,4-di-tert-butyl-6-methylphenol 
• 95-48-7 ortho-cresol 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 2362-12-1 4-Bromo-2-methylphenol 
• 75-65-0 tert-butyl alcohol 
• 64325-12-8 2-(N,N-dimethylaminomethyl)-6-tert-butylphenol 
• 27996-19-6 6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol 
• 67-56-1 methanol 
• 88-18-6 2-tert-Butylphenol 
• 7664-93-9 sulfuric acid 
• 115-11-7 isobutene 
• 7446-70-0 aluminium trichloride 
• 507-20-0 tertiary butyl chloride 
• 98-27-1 2-Methyl-4-t-butylphenol 

Downstream Products

• 96-65-1 bis(3-tert-butyl-4-hydroxy-5-methylphenyl)methane 
• 35579-35-2 2-tert-butyl-6-methyl-cyclohexanone 
• 2417-00-7 3,3'-Di(tert-butyl)-5,5'-dimethyldiphenochinon 
• 616-55-7 2,4-di-tert-butyl-6-methylphenol 
• 95-48-7 ortho-cresol 
• 86559-13-9 4-(3-Brom-2-hydroxy-5-methylbenzyl)-2-tert-butyl-6-methylphenol 
• 3957-69-5 2-tert-butyl-6-methyl-4-thiocyanatophenol 
• 98-27-1 2-Methyl-4-t-butylphenol 
• 2417-00-7 3,3'-Di-tert-butyl-5,5'-dimethyl-diphenochinon 
• 3432-00-6 2,2'-dimethyl-6,6'-di-tert-butyl-4,4'-biphenol 
• 60772-80-7 (2-tert-butyl-6-methylphenyl)methylether 
• 51067-63-1 4-sec-butyl-2-tert-butyl-6-methylphenol 
• 29808-61-5 Iminokohlensaeure-bis-<2-tert.-butyl-6-methyl-phenyl-ester> 
• 57196-28-8 C₃₈H₄₄O₂ 

Relevant articles and documents

Deoxyalkylation of guaiacol using haggite structured V4O6(OH)4

When V2O5 is used for the deoxygenation of guaiacol in methanol, it is reduced in situ to haggite structured V4O6(OH)4. Guaiacol prevents further reduction of the haggite phase in methanol and haggite catalyzes the partial deoxygenation of guaiacol. Haggite is a metastable redox catalyst for the deoxygenation of guaiacol, which follows the reverse Mars-van Krevelen mechanism. In addition, haggite is also a Lewis acid catalyst and catalyzes the alkylation of guaiacol with methanol as the alkylation reagent. The main products of the guaiacol deoxyalkylation are 2,6-dimethylphenol, 2-methoxy-6-methylphenol, 2,4,6-trimethylphenol, 2,3,6-trimethylphenol, 2,3,5,6-tetramethylphenol and 6-methyl-2-tert-butylphenol. Oligomerization takes place during the reaction but it is reversible. When the reaction is performed at 300 °C for 6 h, the 83.5% total selectivity for alkylphenols is achieved with a 99.0% conversion.

Phenol o-position alkylation method

The invention provides a phenol o-position alkylation method which comprises the following step: in the presence of a catalyst, a phenol substance and an alkylating agent react, wherein the catalyst is an aryl zinc salt generated from a reaction of zinc and a phenol compound; the alkylating agent is olefin; the phenol substance comprises polyphenol such as catechol and hydroquinone, and further comprises one to two alkyl groups, or halide based phenols; the alkyl group is straight-chain or branched paraffin with 1-10 carbons. By adopting the phenol o-position alkylation method, the preparation efficiency is greatly improved, and the conversion rate can be further increased. The invention further provides a method for preparing 2,6-di-tert-butyl-4-methylphenol, and a reaction kettle for preparation.

Ruthenium-catalyzed rearrangement of cis-1-ethynyl-2-vinyloxiranes to substituted phenols

Catalytic cyclization of cis-1-ethynyl-2-vinyloxiranes was implemented with TpRuPPh3(CH3CN)2PF6 catalyst (10 mol%), to give 2,6-disubstituted phenols in reasonable yields. Under similar conditions, 1,1,2,2-tetrasubstituted oxirane gave the 2,3,6-trisubstituted phenol with skeleton reorganization. On the basis of 2H- and l3C-labeling results, we propose that the reaction mechanism involves electrocyclization of ruthenium-vinylidene intermediate with cleavage of the carbon-oxygen bond of the epoxide. Georg Thieme Verlag Stuttgart.