22190-47-2

Basic information

• Product Name: 1-[(phenyl)hydroxymethyl]-6,7-dimethoxyisoquinoline
• Synonyms: 1-[(phenyl)hydroxymethyl]-6,7-dimethoxyisoquinoline
• CAS NO: 22190-47-2
• Molecular Weight: 295.338
• Mol File: 22190-47-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[(phenyl)hydroxymethyl]-6,7-dimethoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(phenyl)hydroxymethyl]-6,7-dimethoxyisoquinoline(22190-47-2)
• EPA Substance Registry System: 1-[(phenyl)hydroxymethyl]-6,7-dimethoxyisoquinoline(22190-47-2)

Safety Data

• Hazardous Substances Data: 22190-47-2(Hazardous Substances Data)

Upstream product

• 15248-39-2 6,7-dimethoxyisoquinoline 
• 260552-69-0 (±)-(2-bromophenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol 
• 193551-54-1 (2-Bromo-phenyl)-(6,7-dimethoxy-isoquinolin-1-yl)-methanone 

Relevant articles and documents

Photochemical C?H Hydroxyalkylation of Quinolines and Isoquinolines

We report herein a visible light-mediated C?H hydroxyalkylation of quinolines and isoquinolines that proceeds via a radical path. The process exploits the excited-state reactivity of 4-acyl-1,4-dihydropyridines, which can readily generate acyl radicals upon blue light absorption. By avoiding the need for external oxidants, this radical-generating strategy enables a departure from the classical, oxidative Minisci-type pattern and unlocks a unique reactivity, leading to hydroxyalkylated heteroarenes. Mechanistic investigations provide evidence that a radical-mediated spin-center shift is the key step of the process. The method's mild reaction conditions and high functional group tolerance accounted for the late-stage functionalization of active pharmaceutical ingredients and natural products.

Synthesis of some 6,7-dimethoxy isoquinolines containing benzoyl or alpha-hydroxybenzyl substitutions at position 1

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