221915-97-5

Basic information

• Product Name: (E)-1,1,1-trifluoro-4-(4-hydroxyphenyl)but-3-en-2-one
• Synonyms: (E)-1,1,1-trifluoro-4-(4-hydroxyphenyl)but-3-en-2-one
• CAS NO: 221915-97-5
• Molecular Weight: 216.16
• Mol File: 221915-97-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-1,1,1-trifluoro-4-(4-hydroxyphenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-trifluoro-4-(4-hydroxyphenyl)but-3-en-2-one(221915-97-5)
• EPA Substance Registry System: (E)-1,1,1-trifluoro-4-(4-hydroxyphenyl)but-3-en-2-one(221915-97-5)

Safety Data

• Hazardous Substances Data: 221915-97-5(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant articles and documents

An efficient route to 3-trifluoromethylpyrazole via cyclization/1,5-H shift and its applications in the synthesis of bioactive compounds

A methodology for regioselective synthesis of 3-trifluoromethylpyrazole from the reaction of trifluoromethyl alkenone and tosylhydrazone has been developed. The reaction was proposed to proceed through a tandem cyclization and 1,5-H shift reaction, which can be applied to the synthesis of bioactive compounds like Celecoxib, Mavacoxib, and SC-560.

Trifluoromethyl ketone analogs as selective cPLA2 inhibitors

Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula