22226-37-5

Basic information

• Product Name: α-formyl phenyl acetic acid tropine ester
• CAS NO: 22226-37-5
• Molecular Weight: 287.359
• Mol File: 22226-37-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 400.2±45.0 °C(Predicted)
• Density: 1.18±0.1 g/cm3(Predicted)
• CAS DataBase Reference: α-formyl phenyl acetic acid tropine ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-formyl phenyl acetic acid tropine ester(22226-37-5)
• EPA Substance Registry System: α-formyl phenyl acetic acid tropine ester(22226-37-5)

Safety Data

• Hazardous Substances Data: 22226-37-5(Hazardous Substances Data)

Usage

General Description

α-formyl phenyl acetic acid tropine ester is a chemical compound with potential pharmacological applications. It is derived from tropine, a naturally occurring alkaloid found in plants like Datura stramonium. The compound is synthesized by esterification of tropine with α-formyl phenyl acetic acid. It has been studied for its potential use in the treatment of neurological and psychiatric disorders due to its ability to modulate neurotransmitter systems in the brain. Additionally, it has been investigated for its potential as an analgesic and anti-inflammatory agent. The compound shows promise as a therapeutic agent and may have potential applications in the pharmaceutical industry.

Upstream product

• 5894-79-1 methyl 2-formyl-2-phenylacetate 
• 120-29-6 3-tropanol 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 103-82-2 phenylacetic acid 
• 532-24-1 tropinone 
• 542-05-2 acetonedicarboxylic acid 
• 59216-85-2 α-formyl phenyl acetic acid 

Downstream Products

• 51-55-8 Atropine 

Relevant articles and documents

Synthesis method of atropine sulfate

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of atropine sulfate. The preparation method comprises the following steps: firstly preparing tropine ester, then preparing atropine, salifying to prepare atropine sulfate, and finally refining to obtain the product. In the preparation process of the tropine ester, the reaction temperature is strictly controlled to be 105-111 DEG C, and the crystallization temperature is controlled to be 0-5 DEG C, so that the yield of the tropine ester is improved. In the process of preparing atropine through reduction reaction, palladium-carbon is adopted as a catalyst, and the reaction temperature is strictly controlled to be 10-15 DEG C, so that the product quality is effectively improved. Sulfuric acid is diluted by preparing a sulfuric acid ethanol solution, and the dripping speed of the sulfuric acid ethanol solution is controlled, so that the stable quality of atropine sulfate is ensured.

CRYSTALLINE ATROPINE SULFATE

The present invention relates to crystalline polymorph form of Atropine sulfate and process for the preparation thereof.