2224-10-4 Usage
Description
CARBOXYTOLBUTAMIDE is a metabolite of Tolbutamide, an oral hypoglycemic agent used for the treatment of type 2 diabetes. It is formed by the cytochrome CYP2C8 and CYP2C9 subfamily of P450 enzymes, which are responsible for its biotransformation. CARBOXYTOLBUTAMIDE is an off-white solid and plays a significant role in the metabolism of Tolbutamide.
Uses
Used in Pharmaceutical Industry:
CARBOXYTOLBUTAMIDE is used as a metabolite in the pharmaceutical industry for the treatment of type 2 diabetes. It is formed during the metabolism of Tolbutamide, which helps in lowering blood sugar levels in patients with diabetes.
Used in Drug Metabolism Studies:
CARBOXYTOLBUTAMIDE is used as a subject of study in drug metabolism research. Its formation by the cytochrome CYP2C8 and CYP2C9 subfamily of P450 enzymes provides valuable insights into the metabolic pathways and enzyme interactions involved in the biotransformation of Tolbutamide and other similar drugs.
Used in Quality Control and Analytical Testing:
CARBOXYTOLBUTAMIDE is used as a reference compound in quality control and analytical testing of Tolbutamide and its formulations. It helps in ensuring the purity, potency, and consistency of the drug, as well as in monitoring its metabolism and pharmacokinetics.
Used in Toxicology and Safety Assessment:
CARBOXYTOLBUTAMIDE is used in toxicology and safety assessment studies to evaluate the potential side effects and toxicity of Tolbutamide and its metabolites. Understanding the role of CARBOXYTOLBUTAMIDE in the metabolic pathway of Tolbutamide aids in assessing the safety and efficacy of the drug for therapeutic use.
Check Digit Verification of cas no
The CAS Registry Mumber 2224-10-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2224-10:
(6*2)+(5*2)+(4*2)+(3*4)+(2*1)+(1*0)=44
44 % 10 = 4
So 2224-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2O5S/c1-2-3-8-13-12(17)14-20(18,19)10-6-4-9(5-7-10)11(15)16/h4-7H,2-3,8H2,1H3,(H,15,16)(H2,13,14,17)
2224-10-4Relevant articles and documents
An improved synthesis of N-(butylaminocarbonyl)-4-hydroxymethyl-benzenesulfonamide, one of the metabolites of tolbutamide, and synthesis of its formyl derivative
Makaya,Irie,Shibasaki
, p. 2518 - 2519 (2007/10/02)
An improved synthesis of N-(butylaminocarbonyl)-4-hydroxymethyl-benzenesulfonamide, one of the metabolites of tolbutamide, and its transformation to the formyl derivative are described.
