222412-73-9 Usage
Description
N-4-Phenyl α-Benzylidene-d5 IsobutyrylacetaMide is a deuterated intermediate of deuterated Atorvastatin, a selective and competitive HMG-CoA reductase inhibitor. It is a unique compound that plays a crucial role in the synthesis of Atorvastatin, a drug specifically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Uses
Used in Pharmaceutical Industry:
N-4-Phenyl α-Benzylidene-d5 IsobutyrylacetaMide is used as a key intermediate in the synthesis of Atorvastatin for the treatment of hypercholesterolemia. Its incorporation into the drug molecule aids in the development of a more effective and selective HMG-CoA reductase inhibitor, which helps in lowering elevated LDL-cholesterol and triglyceride levels in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 222412-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,4,1 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 222412-73:
(8*2)+(7*2)+(6*2)+(5*4)+(4*1)+(3*2)+(2*7)+(1*3)=89
89 % 10 = 9
So 222412-73-9 is a valid CAS Registry Number.
222412-73-9Relevant articles and documents
Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part III. Syntheses of [2H5]-, [13C8], and [13C7,15N]atorvastatin and their application in metabolic and pharmacokinetic studies
Woo, Peter W. K.,Hartman, Jon,Hicks, James,Hayes, Roger
, p. 135 - 145 (2007/10/03)
Three stable-isotope-labeled forms of atorvastatin, [2H5], [13C8], and [13C7,15N], were synthesized. They were utilized primarily for metabolic mapping and pharmacokinetic studies of bioequivalence. Analytical assays were performed by using LC/MS/MS methodologies.
