22244-94-6

Basic information

• Product Name: Imidazo[1,2-a]pyridine, 3-nitro-2-(4-nitrophenyl)-
• CAS NO: 22244-94-6
• Molecular Formula: C13H8N4O4
• Molecular Weight: 284.231
• Mol File: 22244-94-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyridine, 3-nitro-2-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine, 3-nitro-2-(4-nitrophenyl)-(22244-94-6)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine, 3-nitro-2-(4-nitrophenyl)-(22244-94-6)

Safety Data

• Hazardous Substances Data: 22244-94-6(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 75-52-5 nitromethane 
• 555-16-8 4-nitrobenzaldehdye 
• 3156-41-0 1-nitro-4-(2-nitrovinyl)benzene 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 24067-17-2 4-nitrophenylboronic acid 
• 4926-52-7 2-chloro-3-nitroimidazo[1,2-a]pyridine 
• 22244-95-7 3-bromo-2-(4'-nitrophenyl)imidazo[1,2-a]pyridine 
• 138023-18-4 2-(4-Bromophenyl)-3-bromoimidazo<1,2-a>pyridine 
• 4044-95-5 2-Phenyl-3-bromoimidazo<1,2-a>pyridine 

Relevant articles and documents

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Synthesis of 3-Nitro-2-arylimidazo[1,2- a ]pyridines Using Sodium Dichloro?-iodide

Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tol

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.