22246-13-5

Basic information

• Product Name: 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• Synonyms: 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE;AKOS BB-9801;6-amino-3,4-dihydro-2(1 )-quinalinone;6-AMino-1,3,4-trihydro-quinolin-2-one;6-aMino-3,4-dihydro-2(1H )-quinalinone;6-amino-3,4-dihydrocarbostyril;6-Amino-3,4-dihydroquinoline-2(1H)-one
• CAS NO: 22246-13-5
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Product Categories: pharmacetical
• Mol File: 22246-13-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 423 °C at 760 mmHg
• Flash Point: 209.7 °C
• Appearance: /
• Density: 1.237 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(22246-13-5)
• EPA Substance Registry System: 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(22246-13-5)

Safety Data

• Hazardous Substances Data: 22246-13-5(Hazardous Substances Data)

Usage

Description

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is an organic compound with the molecular formula C10H10N2O. It is a derivative of quinoline, featuring an amino group at the 6th position and a dihydro structure. 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is used as a key intermediate in the synthesis of various cardiotonic agents. These agents are essential for the treatment of heart-related conditions, as they help to strengthen the contractions of the heart muscles, thereby improving cardiac function.
Used in Chemical Synthesis:
In the chemical industry, 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE serves as a versatile building block for the creation of a wide range of compounds with diverse applications. Its unique structure allows for further functionalization and modification, making it a valuable component in the development of new drugs, dyes, and other specialty chemicals.

Upstream product

• 22246-16-8 6-nitro-3,4-dihydro-1H-quinolin-2-one 
• 62-53-3 aniline 
• 3460-04-6 3-chloro-N-phenylpropionamide 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 

Downstream Products

• 99139-81-8 N-(2-oxo-1,2,3,4-tetrahydro-[6]quinolyl)-benzamide 
• 108285-10-5 6-hydrazinyl-3,4-dihydroquinolin-2(7H)-one 
• 1192709-19-5 butyl 2-(1-(2-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)acetate 
• 1192708-40-9 6-(5-fluoro-4-(4-(hydroxymethyl)piperidin-1-yl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one 
• 1192709-03-7 4-(cyclopropylamino)-2-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 
• 1192708-48-7 6-(4-(cyclopropylamino)-5-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one 
• 1192709-11-7 4-(4-methoxyphenylamino)-2-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 
• 1192712-29-0 C₃₁H₃₅FN₆O₅ 
• 1192712-32-5 C₂₉H₃₅N₇O₃ 
• 1192712-35-8 C₂₇H₂₉FN₆O₃ 
• 1192712-38-1 C₃₂H₃₃N₇O₃ 
• 1192712-40-5 benzyl (1s,4s)-4-(5-cyclopropyl-2-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)pyrimidin-4-ylamino)cyclohexylcarbamate 
• 1192711-56-0 tert-butyl (1-(5-fluoro-2-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)pyrimidin-4-yl)piperidin-4-yl)methylcarbamate 
• 1564274-98-1 6-(4H-1,2,4-triazol-4-yl)-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY

Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Preparation method of 6-hydroxy-3,4-dihydro-2(1H)quinolinone

The invention belongs to the field of preparation of intermediates in chemical engineering, and particularly relates to a preparation method of 6-hydroxy-3,4-dihydro-2(1H)quinolinone. The preparationmethod comprises the following steps of using aniline and 3-chloropropionyl chloride as raw materials; performing cyclization, nitrification, reduction and diazotization hydrolysis, so as to synthesize the target product, namely 6-hydroxy-3,4-dihydro-2(1H)quinolinone. The preparation method has the advantages that the reaction conditions are mild, the cost is reduced, and the yield rate is increased.

INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4)

Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.