22249-33-8Relevant articles and documents
Synthesis of fused bicyclic rings by tandem radical ring expansion/cyclization: Evaluating competing intramolecular reactions
Wang, Cunxiao,Gu, Xin,Yu, Marvin S.,Curran, Dennis P.
, p. 8355 - 8370 (2007/10/03)
One- and three-carbon 'Dowd-Beckwith' ring expansions of cyclopentanones and cyclohexanones are generally successful, but tandem expansion/cyclization reactions can be compromised by competing processes. An evaluation of the competition between ring expansion, 1,5-hydrogen transfer, and 6-exo cyclization provides information on how to design successful tandem expansion cyclization sequences.