2225-19-6

Basic information

• Product Name: Ethanesulfonamide, N-phenyl-
• CAS NO: 2225-19-6
• Molecular Formula: C8H11NO2S
• Molecular Weight: 185.247
• Mol File: 2225-19-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethanesulfonamide, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanesulfonamide, N-phenyl-(2225-19-6)
• EPA Substance Registry System: Ethanesulfonamide, N-phenyl-(2225-19-6)

Safety Data

• Hazardous Substances Data: 2225-19-6(Hazardous Substances Data)

Upstream product

• 1520-70-3 Ethanesulfonamide 
• 873-55-2 sodium benzenesulfonate 
• 594-45-6 ethanesulfonic acid 
• 62-53-3 aniline 
• 70284-09-2 1-ethanesulfonyl azide 
• 98-80-6 phenylboronic acid 
• 13223-06-8 ethanesulfonic anhydride 
• 594-44-5 Ethanesulfonyl chloride 
• 71-43-2 benzene 

Downstream Products

• 103040-63-7 N-acetyl-N-ethanesulfonyl-2,4-dichloro-aniline 
• 107037-63-8 1-[2-(4-Ethanesulfonylamino-phenyl)-2-hydroxy-ethyl]-3-methyl-3H-imidazol-1-ium; chloride 
• 107037-53-6 1-[2-(4-Ethanesulfonylamino-phenyl)-2-oxo-ethyl]-3-methyl-3H-imidazol-1-ium; chloride 
• 265995-52-6 N-phenyl-2-hydroxyproanesulfonamide mesylate 
• 265995-46-8 N-phenyl-2-hydroxypropanesulfonamide 
• 107037-69-4 Ethanesulfonic acid [4-(2-chloro-acetyl)-phenyl]-amide 
• 23091-52-3 Ethanesulfonic acid phenyl-(1,1,2,2-tetrachloro-2-fluoro-ethylsulfanyl)-amide 
• 90945-12-3 Aethansulfonsaeure- 
• 93-98-1 N-phenyl benzoyl amide 
• 91013-01-3 N-acetyl-N-ethanesulfonyl-aniline 

Relevant articles and documents

Lewis Base Promoted, Direct 1,4-Conjugate Addition to Quinone Imine Ketals: Efficient Access to Unsymmetrical Diaryl Sulfones

An alternative approach with eco-friendliness and high efficiency for the preparation of unsymmetrical diaryl sulfones has been developed. The strategy takes advantage of the reaction of sulfonyl hydrazides with quinone imine ketals catalyzed by DABCO (triethylenediamine) in ethanol. This transformation proceeds via a Lewis base promoted, direct 1,4-conjugate addition/sulfonylation/alcohol elimination reaction sequence. The protocol provides an efficient approach to access an array of diverse unsymmetrical diaryl and heterodiaryl sulfones, aryl alkyl sulfones and aryl vinyl sulfones in good to excellent yields.

Synthesis of CF3CH2-Containing Indolines by Transition-Metal-Free Aryltrifluoromethylation of Unactivated Alkenes

With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CF3SO2Na (Langlois' reagent), affording CF3CH2-containing indolines and tetrahydroisoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.