22255-13-6 Usage
Description
Guajavarin, a flavonoid derivative, is a compound with significant biological activities and potential applications in various fields. It is characterized by its unique chemical structure and properties, which contribute to its diverse uses.
Uses
Used in Pharmaceutical Industry:
Guajavarin is used as a pharmaceutical agent for its anticancer properties. It exhibits antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in the late G1 phase of the cell cycle. Its ability to inhibit PI3-kinase activity and slightly inhibit PIP kinase activity also contributes to its potential as a therapeutic agent.
Used in Drug Delivery Systems:
In the field of drug delivery, guajavarin can be employed to enhance the efficacy and bioavailability of various pharmaceutical compounds. Its unique chemical properties allow for the development of novel drug delivery systems, such as organic and metallic nanoparticles, which can improve the delivery and therapeutic outcomes of associated drugs.
Used in Research and Development:
As a primary reference substance with assigned absolute purity, guajavarin is also utilized in research and development for the study of its biological activities and potential applications in various industries. The exact purity value can be found on the certificate provided by the producer, PhytoLab GmbH & Co. KG.
Biochem/physiol Actions
quercetin 3-O-α-L-arabinopyranoside was shown to inhibit the activity of glucose-6-phosphatase.
Check Digit Verification of cas no
The CAS Registry Mumber 22255-13-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,5 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22255-13:
(7*2)+(6*2)+(5*2)+(4*5)+(3*5)+(2*1)+(1*3)=76
76 % 10 = 6
So 22255-13-6 is a valid CAS Registry Number.
22255-13-6Relevant articles and documents
Highly Promiscuous Flavonoid 3- O-Glycosyltransferase from Scutellaria baicalensis
Wang, Zilong,Wang, Shuang,Xu, Zheng,Li, Mingwei,Chen, Kuan,Zhang, Yaqun,Hu, Zhimin,Zhang, Meng,Zhang, Zhiyong,Qiao, Xue,Ye, Min
supporting information, p. 2241 - 2245 (2019/03/19)
A highly regio-specific and donor-promiscuous 3-O-glycosyltransferase, Sb3GT1 (UGT78B4), was discovered from Scutellaria baicalensis. Sb3GT1 could accept five sugar donors (UDP-Glc/-Gal/-GlcNAc/-Xyl/-Ara) to catalyze 3-O-glycosylation of 17 flavonols, and the conversion rates could be >98%. Five new glycosides were obtained by scaled-up enzymatic catalysis. Molecular modeling and site-directed mutagenesis revealed that G15 and P187 were critical catalytic residues for the donor promiscuity. Sb3GT1 could be a promising catalyst to increase structural diversity of flavonoid 3-O-glycosides.