222713-07-7Relevant articles and documents
A synthesis of racemic thalidomide
Chang, Meng-Yang,Chen, Shui-Tein,Chang, Nein-Chen
, p. 1375 - 1382 (2003)
A synthesis of racemic thalidomide is described using formal [3+3] cycloaddition strategy as the key step. The total yield of thalidomide was 30% in three steps from ester 2.
Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFα-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine
Luzzio, Frederick A.,Mayorov, Alexander V.,Ng, Sylvia S. W.,Kruger, Erwin A.,Figg, William D.
, p. 3793 - 3799 (2007/10/03)
Versatile synthesis of the teratogenic, TNFα-modulatory, and antiangiogenic thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine (1) and its direct antiangiogenic properties are described. With thalidomide or thalidomide derivatives as precursors, the synthesis involved either carbonyl reduction/thiation-desulfurization or carbonyl reduction/acyliminium ion reduction protocols. Compared to earlier studies with thalidomide, which was only active with microsomal treatment, 1 exhibited marginal inhibitory activity in the rat aortic ring assay, thereby demonstrating the requirement for metabolic activation.