22276-95-5

Basic information

• Product Name: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine;7-bromo-5-chloro-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene;7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-;5-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidine ,98%;5-Bromo-4-chloro-7H-pyrro...;5-broMo-4-chloro-7H-pyrrolo[2;7-BroMo-6-chloro-7-deazapurine;4-chloro-5-bromo-7H-pyrrolo[2,3-d]pyrimidine
• CAS NO: 22276-95-5
• Molecular Formula: C₆H₃BrClN₃
• Molecular Weight: 232.47
• EINECS: 1312995-182-4
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 22276-95-5.mol
• Article Data: 56

Chemical Properties

• Melting Point: 221-225℃
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: /
• Density: 1.996 g/cm³
• Vapor Pressure: 9.14E-06mmHg at 25°C
• Refractive Index: 1.746
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.43±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine(22276-95-5)
• EPA Substance Registry System: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine(22276-95-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 22276-95-5(Hazardous Substances Data)

Usage

Description

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic compound characterized by the presence of a pyrrolo[2,3-d]pyrimidine ring system with a bromine atom at the 5th position and a chlorine atom at the 4th position. This chemical structure endows it with unique properties that make it a versatile building block in various chemical and pharmaceutical applications.

Uses

Used in Organic Synthesis:
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is used as a key intermediate for the synthesis of various complex organic molecules. Its unique structural features allow for further functionalization and modification, making it a valuable component in the development of novel chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is used as a building block for the development of new drugs. Its chemical properties enable it to be incorporated into drug candidates targeting a wide range of therapeutic areas, including oncology, neurology, and cardiovascular diseases.
Used in Agrochemicals:
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is also utilized as a starting material in the agrochemical industry for the synthesis of various pesticides and insecticides. Its structural diversity allows for the development of new compounds with improved efficacy and selectivity against target pests.
Used in Dyestuff Industry:
In the dyestuff industry, 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine is employed as a crucial intermediate for the production of various dyes and pigments. Its unique chromophoric properties contribute to the development of new colorants with enhanced color strength, stability, and application performance.

InChI:InChI=1/C6H3BrClN3/c7-3-1-9-6-4(3)5(8)10-2-11-6/h1-2H,(H,9,10,11)

Upstream product

• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 144927-56-0 4-chloro-5-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine 
• 952429-11-7 (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diyl dibenzoate 
• 24391-41-1 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 
• 123148-83-4 7-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 115093-88-4 4-amino-5-bromo-7-<(2-hydroxyethoxy)methyl>pyrrolo<2,3-d>pyrimidine 
• 157666-32-5 4-chloro-7-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-5-methyl-7H-pyrrolo<2,3-d>pyrimidine 
• 164514-17-4 5-bromo-4-chloro-7-(α-L-lyxofuranosyl)pyrrolo[2,3-d]pyrimidine 
• 21193-80-6 5-Bromotubercidin 
• 21193-61-3 4-amino-5-bromo-7-(β-L-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 952429-12-8 5-bromo-4-chloro-7-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 582313-57-3 4-chloro-7-fluoro-7-deazapurine 
• 144927-57-1 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1618-36-6 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 157666-31-4 5-bromo-4-chloro-7-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 

Relevant articles and documents

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