22282-65-1

Basic information

• Product Name: 4-Iodo-2-methylpyridine
• Synonyms: 4-Iodo-2-methylpyridine
• CAS NO: 22282-65-1
• Molecular Formula: C₆H₆IN
• Molecular Weight: 219.02301
• Product Categories: pharmacetical;Pyridines
• Mol File: 22282-65-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 222.12 °C at 760 mmHg
• Flash Point: 88.135 °C
• Appearance: /
• Density: 1.81 g/cm³
• Vapor Pressure: 0.154mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-Iodo-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-2-methylpyridine(22282-65-1)
• EPA Substance Registry System: 4-Iodo-2-methylpyridine(22282-65-1)

Safety Data

• Hazardous Substances Data: 22282-65-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-2-methylpyridine is a chemical compound with the molecular formula C6H6IN. It is a pyridine derivative that contains a methyl group and an iodine atom. 4-Iodo-2-methylpyridine is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic intermediates. It is also used as a building block in the production of various organic compounds, including chiral ligands and biologically active molecules. 4-Iodo-2-methylpyridine is a versatile reagent that has found application in a wide range of chemical reactions, making it a valuable tool in the field of organic chemistry. However, it is important to handle this compound with care due to its potential hazards, including its irritant and toxic properties.

InChI:InChI=1/C6H6IN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3

Upstream product

• 18437-58-6 3-methyl-4-pyridinamine 
• 79534-90-0 2-methyl-4-(trimethylstannyl)pyridine 
• 565237-08-3 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-chloropyridine 
• 75-36-5 acetyl chloride 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 
• 1121-76-2 4-chloropyridine N-oxide 
• 22282-99-1 4-bromo-2-methylpyridine 
• 3678-63-5 4-chIoro-2-methylpyridine 

Downstream Products

• 712-61-8 2,2'-dimethyl-4,4'-bipyridine 
• 33474-76-9 2-methyl-4(E)-styrylpyridine 
• 84586-39-0 (E)-2-methyl-4-pyridineacrylonitrile 
• 84586-38-9 (E)-ethyl 3-(2-methylpyridin-4-yl)acrylate 
• 761426-39-5 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)pyridine 
• 761426-51-1 2-methyl-4-((trimethylsilyl)ethynyl)pyridine 
• 1206629-05-1 methyl 3-(4-((2-methylpyridin-4-yl)ethynyl)phenyl)propanoate 
• 1206629-06-2 3-(4-((2-methylpyridin-4-yl)ethynyl)phenyl)propanoic acid 

Relevant articles and documents

Rapid and efficient copper-catalyzed finkelstein reaction of (hetero)aromatics under continuous-flow conditions

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.

IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES

4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency.

Studies on Organometallic Compounds. II. Facile and Convenient Method for the Synthesis of Idoazines through Iododestannation of Trimethylstannylazines

Trimethylsatannyl and bis(trimethylstannyl) derivatives of pyridine, quinoline, and isoquinoline were prepared from the corresponding halo and dihalo (chloro or bromo) derivatives and trimethylstannyl sodium, which was generated in situ from chlorotrimethylsatannane and sodium.These stannyl derivatives readily underwent iododestannation on treatment with iodine to produce the corresponding iodo and diiodo derivatives of pyridine, quinoline, and isoquinoline, respectively, in good yields.Keywords -trimethylsannylazine; bis(trimethylstannyl)azine; iodoazine; diiodoazine; iododestannation; trimethylstannyl sodium; chlorotrimethylstannane