222960-38-5Relevant articles and documents
Novel approach to the synthesis of istaroxime
Liang,Guo,Jiang
, p. 2643 - 2647 (2017/12/26)
Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.
AN IMPROVED SYNTHETIC ROUTE TO AMONOXYPROPYLAMINE (APA) AND RELATED HOMOLOGS
Pankaskie, Marvin C.,Scholtz, Stephen A.
, p. 339 - 344 (2007/10/02)
Aminoxypropylamine (APA) has been found to be a potent inhibitor of several enzymatic pathways involved in the biosynthesis of the naturally occuring polyamines putrescine, spermidine, and spermine.This report describes a convenient, three-step synthesis of APA, as well as its ethyl and butyl homologs, utilizing starting materials and intermediates useful in the preparation of other related aminoxyalkylamines.