223131-45-1

Basic information

• Product Name: 1-fluoromethyl-4-isothiocyanato-cyclohexane
• Synonyms: 1-fluoromethyl-4-isothiocyanato-cyclohexane
• CAS NO: 223131-45-1
• Molecular Weight: 173.254
• Mol File: 223131-45-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-fluoromethyl-4-isothiocyanato-cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoromethyl-4-isothiocyanato-cyclohexane(223131-45-1)
• EPA Substance Registry System: 1-fluoromethyl-4-isothiocyanato-cyclohexane(223131-45-1)

Safety Data

• Hazardous Substances Data: 223131-45-1(Hazardous Substances Data)

Upstream product

• 223131-25-7 ((1S,4S)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzenesulfonate 
• 223131-01-9 tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate 
• 223131-33-7 N-[cis-4-(fluoromethyl)cyclohexyl]-O-t-butylcarbamate 
• 30134-98-6 ((1r,4r)-4-aminocyclohexyl)methanol 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 
• 185815-66-1 cis-4-fluoromethylcyclohexylamine 

Relevant articles and documents

Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1 -thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H3 receptor

The synthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1 -thiocarbonamide (VUF 5000) 3, a fluorinated analogue of the potent (pA2 value of 8.9 ± 0.1, K(i) = 4.3 ± 0.9 nM) histamine H3 receptor antagonist thioperamide 2 is described. After the establishment of the H3 antagonistic activity of VUF 5000, pA2 value = 9.0 ± 0.2, K(i) = 2.3 ± 0.5 nM, a four step synthesis for the radiolabelling of VUF 5000 with 18F (half life 110 min) was developed. Within 4 hours of the end of the bombartment, [18F]VUF 5000 was obtained with an average radiochemical yield of 23% (decay corrected) and a specific activity > 96.2 TBq/μmol (2.6 Ci/μmol).