22314-94-9

Basic information

• Product Name: 3-methylharman
• Synonyms: 3-methylharman;1,3-Dimethyl-9H-pyrido[3,4-b]indole;1,3-Dimethyl-β-carboline
• CAS NO: 22314-94-9
• Molecular Formula: C13H12 N2
• Molecular Weight: 196.25
• Mol File: 22314-94-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 385.9°Cat760mmHg
• Flash Point: 172.4°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 8.18E-06mmHg at 25°C
• Refractive Index: 1.723
• CAS DataBase Reference: 3-methylharman(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylharman(22314-94-9)
• EPA Substance Registry System: 3-methylharman(22314-94-9)

Safety Data

• Hazardous Substances Data: 22314-94-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2/c1-8-7-11-10-5-3-4-6-12(10)15-13(11)9(2)14-8/h3-7,15H,1-2H3

Upstream product

• 1015760-82-3 (E)-N-(2-(3-oxobut-1-en-1-yl)phenyl)benzenesulfonamide 
• 151721-32-3 N-benzenesulfonyl-o-aminobenzaldehyde 
• 615-43-0 2-iodophenylamine 
• 1298035-46-7 N-(2-iodophenyl)-2,4-dimethyloxazol-5-amine 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 1298035-44-5 2-acetamido-N-(2-iodophenyl)propanamide 
• 1298035-42-3 tert-butyl 1-(2-iodophenylamino)-1-oxopropan-2-ylcarbamate 
• 1132804-51-3 C₉H₁₁IN₂O 
• 132922-37-3 2-(1H-indol-3-yl)-N-methoxy-N-methyl-acetamide 
• 87-51-4 indole-3-acetic acid 
• 1201-26-9 3-(1H-indolyl)acetone 
• 738608-55-4 1-(2-acetyl-1H-indol-3-yl)-propan-2-one 

Relevant articles and documents

-

-

β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties

[Figure not available: see fulltext.] Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, and their structural analogs by thermolysis of substituted 4-aryl-3-azidopyridines was developed, and their optical properties were studied.

SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS

Substituted pyrido[3,4-b]indoles and their use as pharmaceuticals The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula I, in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.