22316-25-2

Basic information

• Product Name: 7-chloro-1-ethyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
• CAS NO: 22316-25-2
• Molecular Formula: C₁₇H₁₅ClN₂O₂
• Molecular Weight: 314.7662
• Mol File: 22316-25-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 642.5°C at 760 mmHg
• Flash Point: 342.4°C
• Density: 1.296g/cm³
• Vapor Pressure: 2.11E-16mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 7-chloro-1-ethyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1-ethyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione(22316-25-2)
• EPA Substance Registry System: 7-chloro-1-ethyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione(22316-25-2)

Safety Data

• Hazardous Substances Data: 22316-25-2(Hazardous Substances Data)

Upstream product

• 62476-15-7 4-chloro-N¹-ethylbenzene-1,2-diamine 
• 603-33-8 triphenylbismuthane 
• 37385-80-1 7-chloro-1-ethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 28491-95-4 N-ethyl-4-chloro-2-nitro-aniline 

Relevant articles and documents

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.

Benzodiazepines with psychotropic activity. 3. N-aryl- and N-heteroaryl-1H-1,5-benzodiazepine-2,4-(3H,5H)-diones

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