22316-59-2

Basic information

• Product Name: 2-methyl-3-(4-methylphenyl)quinazolin-4(3H)-one
• Synonyms: 2-methyl-3-(4-methylphenyl)-3,4-dihydroquinazolin-4-one; 2-Methyl-3-(4-methylphenyl)quinazolin-4(3H)-one; 2-Methyl-3-p-tolyl-3H-quinazolin-4-one; 4(3H)-quinazolinone, 2-methyl-3-(4-methylphenyl)-; Quinazolin-4(3H)-one, 2-methyl-3-(4-methylphenyl)-; Quinazolin-4(3H)-one, 2-methyl-3-(p-tolyl)-
• CAS NO: 22316-59-2
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.2952
• Mol File: 22316-59-2.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 424.9°C at 760 mmHg
• Flash Point: 210.8°C
• Density: 1.16g/cm³
• Vapor Pressure: 1.99E-07mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 2-methyl-3-(4-methylphenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-(4-methylphenyl)quinazolin-4(3H)-one(22316-59-2)
• EPA Substance Registry System: 2-methyl-3-(4-methylphenyl)quinazolin-4(3H)-one(22316-59-2)

Safety Data

• Hazardous Substances Data: 22316-59-2(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 89-52-1 o-acetylamino-benzoic acid 
• 108-24-7 acetic anhydride 
• 118-92-3 anthranilic acid 
• 849585-22-4 LACTIC ACID 
• 32212-38-7 2-amino-N-(4-methylphenyl)benzamide 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 134-20-3 2-carbomethoxyaniline 
• 75-05-8 acetonitrile 
• 99-99-0 1-methyl-4-nitrobenzene 
• 615-43-0 2-iodophenylamine 
• 6968-24-7 2,6-Dibromo-4-methylaniline 
• 123-54-6 acetylacetone 
• 1026085-87-9 2-p-Tolyliminomethyleneamino-benzoic acid ethyl ester 

Downstream Products

• 1047648-00-9 (E)-2-(4-chlorostyryl)-3-(p-tolyl)quinazolin-4(3H)-one 
• 142888-59-3 (E)-2-(4-methoxystyryl)-3-(p-tolyl)quinazolin-4(3H)-one 
• 352639-64-6 (E)-2-(4-fluorostyryl)-3-(p-tolyl)quinazolin-4(3H)-one 
• 142888-57-1 3-p-tolyl-2-styryl-3,4-dihydro-4-quinazolone 
• 73283-28-0 2-(3,3,3-Trifluoroacetonyl)-3-p-tolyl-4(3H)-quinazolinone 
• 128458-15-1 2-[2-(4-Bromo-phenyl)-5-p-tolyl-2H-pyrazol-3-yl]-3-p-tolyl-3H-quinazolin-4-one 
• 128458-35-5 2-(2,5-Di-p-tolyl-2H-pyrazol-3-yl)-3-p-tolyl-3H-quinazolin-4-one 
• 128458-11-7 2-[2-(4-Bromo-phenyl)-5-phenyl-2H-pyrazol-3-yl]-3-p-tolyl-3H-quinazolin-4-one 
• 128458-31-1 2-(5-Phenyl-2-p-tolyl-2H-pyrazol-3-yl)-3-p-tolyl-3H-quinazolin-4-one 
• 128458-27-5 2-(2-Phenyl-5-p-tolyl-2H-pyrazol-3-yl)-3-p-tolyl-3H-quinazolin-4-one 
• 128458-23-1 2-(2,5-Diphenyl-2H-pyrazol-3-yl)-3-p-tolyl-3H-quinazolin-4-one 
• 128458-05-9 3-p-Tolyl-2-(5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-3H-quinazolin-4-one 
• 128458-01-5 2-(5-Phenyl-3,4-dihydro-2H-pyrazol-3-yl)-3-p-tolyl-3H-quinazolin-4-one 

Relevant articles and documents

Chemical transformations of reaction products of 2-methyl-3-(4-tolyl)-4(3H) -quinazolone with benzil and its 4,4′-derivatives

The reaction of 2-methyl-3-(4-tolyl)-4(3H)-quinazolone with benzil produces 2-[(Z)-3-oxo-2,3-diphenylprop-1-enyl]-3-(4-tolyl)-4(3H)-quinazolone, which is readily transformed into 2-(3,3-diphenylsuccinimido)-N-(4-tolyl)benzamide on dissolution in organic water-containing solvents. The rearrangement mechanism was suggested and investigated by the quantum chemical PM3 method. Springer Science+Business Media, Inc. 2007.

Development of novel Schiff base fluorophores for selective detection of Cu2+ ions in seawater using test strips

A novel Schiff bases of 2-((2-aminophenylimino)methyl)-3-phenyl-4(3H)-quinazolinone (3a), 2-((2-aminophenylimino)methyl)-3-(4-tolyl)-4(3H)-quinazolinone (3b), and 2-((2-aminophenylimino)methyl)-3-(4-anisyl)-4(3H)-quinazolinone (3c) were synthesized and ch

α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and other N-heterocyclesviadecarboxylative oxidative annulation reaction

A metal-free and efficient procedure for the synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and indolo[1,2-a]quinoxaline has been developed. The key features of our method include thein situgeneration of aldehyde from α-hydroxy acid in the presence of TBHP (tert-butyl hydrogen peroxide), and further condensation with various amines, followed by intramolecular cyclization and subsequent oxidation to afford the corresponding quinoxalines, quinazolinones derivatives in moderate to high yields.

Palladium-catalyzed four-component carbonylative synthesis of 2,3-disubstituted quinazolin-4(3H)-ones: Convenient methaqualone preparation

A palladium-catalyzed four-component carbonylative cyclization reaction for the synthesis of 2,3-disubstituted quinazolin-4(3H)-ones has been developed. A range of different 2,3-disubstituted quinazolin-4(3H)-one derivatives were prepared in moderate to good yields employing simple and readily accessible 2-iodoanilines, nitro compounds and acid anhydrides as the synthetic precursors. Mo(CO)6 acted both as a solid CO source and a reductant. Notably, methaqualone as a sedative and hypnotic medication can be prepared easily in 68% yield (4b) under our conditions as well.