223387-33-5Relevant articles and documents
Synthesis of galloyl-substituted procyanidin B4 series, and their DPPH radical scavenging activity and DNA polymerase inhibitory activity
Sakuda, Hironori,Saito, Akiko,Mizushina, Yoshiyuki,Yoshida, Hiromi,Tanaka, Akira,Nakajima, Noriyuki
, p. 175 - 188 (2006)
Synthesis of galloyl-substituted procyanidin B4 series, 3-O-gallate, 3″-O-gallate and 3,3″-di-O-gallate, is described. Condensationof the electrophile derived from (+)-catechin with the nucleophile derived from (-)-epicatechin the presence of TMSOTf as a
Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
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Page/Page column 7, (2010/11/25)
Improved processes for the preparation of tetra-O-benzyl protected catechin, for the coupling of the tetra-O-benzyl protected catechin or epicatechin with a C-4 activated, tetra-O-benzyl protected epicatechin for the galloylation of the epicatechin-(4β,8)-catechin or -epicatechin dimer-the dimer digallates, and for the deprotection (i.e., debenzylation) of the protected epicatechin dimers and protected epicatechin dimer digallates are disclosed.
Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases
Saito, Akiko,Mizushina, Yoshiyuki,Ikawa, Hiroshi,Yoshida, Hiromi,Doi, Yuki,Tanaka, Akira,Nakajima, Noriyuki
, p. 2759 - 2771 (2007/10/03)
Six galloyl-substituted procyanidin B1 and B2, 3-O-gallate, 3″-O-gallate, and 3,3″-di-O-gallate, were systematically synthesized with the condensation method using TMSOTf as a catalyst. Their ability of DPPH radical scavenging activity and DNA polymerase inhibitory activity were also investigated. The results indicated that the galloyl group of these compounds is very important for both activities. 3,3″-Di-O-gallate dimers acted as strong inhibitor against DNA polymerase α and β, whereas the desgalloyl and monogalloyl compounds did not exhibit any appreciable inhibitory activity against the DNA polymerase β.