223394-25-0

Basic information

• Product Name: (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine
• Synonyms: (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine
• CAS NO: 223394-25-0
• Molecular Weight: 321.373
• Mol File: 223394-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine(223394-25-0)
• EPA Substance Registry System: (2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonylmethylen)-5-phenyl-4-methyl-1,3-oxazolidine(223394-25-0)

Safety Data

• Hazardous Substances Data: 223394-25-0(Hazardous Substances Data)

Upstream product

• 10601-80-6 ethyl 3,3-diethoxypropanoate 

Downstream Products

• 223394-27-2 (1'R,2'R,2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonyl-2'-phenyl-1-hydroxyethyl)-4-methyl-5-phenyl-1,3-oxazolidine 
• 223394-34-1 (4R,5R,3'S,4'R)-5-(2'-aza-2',3'-dimethyl-4'-hydroxy-4'-phenyl-butyl)-2,2-dimethyl-4-furyl-1,3-dioxane 
• 223394-32-9 (1R,2S,5R,6R)-3-aza-1-phenyl-6-furyl-5-hydroxymethyl-2,3-dimethyl-1,6-hexanediol 
• 223394-29-4 (1'R,2'R,2S,4S,5R)-N-ethoxycarbonyl-2-(1'-ethoxycarbonyl-2'-furyl-2'-hydroxyethyl)-4-methyl-5-phenyl-1,3-oxazolidine 

Relevant articles and documents

Diastereoselective aldol condensation with 2-(β- ethoxycarbonyl)oxazolidine derived from norephedrine. A chiral masked synthon of ethyl formylacetate

Deprotonation of chiral masked synthetic equivalents of ethyl glyoxalate, derived from norephedrine, with a novel base formed by addition of tert-BuLi to tert-butyl formate, and subsequent reaction with aromatic aldehydes yields β-hydroxy esters in good yield and moderate to excellent diastereomeric excesses. Reductive transformation of the condensation products, and elimination of the chiral appendage leads to enantiomerically pure 2-aminomethyl-1,3-propanediol derivatives.