22353-52-2

Basic information

• Product Name: 5-Chloro-2-methoxy-3-nitropyridine
• Synonyms: 5-Chloro-2-methoxy-3-nitropyridine
• CAS NO: 22353-52-2
• Molecular Formula: C6H5ClN2O3
• Molecular Weight: 188.57
• Product Categories: blocks;NitroCompounds;Pyridines;Pyridine;Heterocycle-Pyridine series
• Mol File: 22353-52-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 89-92 °C
• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 111.1 °C
• Appearance: /
• Density: 1.445 g/cm³
• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.92±0.20(Predicted)
• CAS DataBase Reference: 5-Chloro-2-methoxy-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-methoxy-3-nitropyridine(22353-52-2)
• EPA Substance Registry System: 5-Chloro-2-methoxy-3-nitropyridine(22353-52-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 22353-52-2(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-methoxy-3-nitropyridine is a chemical compound with the molecular formula C6H5ClNO3. It is a yellow solid that is used in organic synthesis as a building block for pharmaceuticals and agrochemicals. 5-Chloro-2-methoxy-3-nitropyridine is known for its nitro and chloro functional groups, which make it useful for a variety of chemical reactions and transformations. It is commonly utilized in the production of drugs and pesticides as well as other fine chemicals. 5-Chloro-2-methoxy-3-nitropyridine is an important intermediate in the synthesis of various biologically active compounds and has applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C6H5ClN2O3/c1-12-6-5(9(10)11)2-4(7)3-8-6/h2-3H,1H3

Upstream product

• 67-56-1 methanol 
• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 886373-70-2 3-amino-5-chloro-2-methoxypyridine 

Relevant articles and documents

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

PYRIDIN-2(1H)-ONE DERIVATIVES AS JAK INHIBITORS

New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).